United States securities and exchange commission logo June 9, 2023 Julie Ryan Vice President, Finance GH Research PLC Joshua Dawson House Dawson Street Dublin 2 D02 RY95 Ireland Re: GH Research PLC Form 20-F for the Fiscal Year Ended December 31, 2022 Filed March 9, 2023 File No. 001-40530 Dear Julie Ryan: We have completed our review of your filing. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Sincerely, Division of Corporation Finance Office of Life Sciences