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<div style="font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">1. Corporate information</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">GH Research PLC (the “Company”) was incorporated on March 29, 2021. The registered office of the Company is located at 28 Baggot Street Lower, Dublin 2, Ireland. The company controls one wholly-owned subsidiary: GH Research Ireland Limited, which was incorporated in Dublin, Ireland on October 16, 2018. The Company and its subsidiary form the GH Research Group (the “Group”).</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The Group is a clinical-stage biopharmaceutical company dedicated to transforming the treatment of psychiatric and neurological disorders. Its initial focus is on developing the novel and proprietary 5-MeO-DMT therapies for the treatment of patients with Treatment Resistant Depression, or TRD. Its portfolio currently includes GH001, a proprietary inhalable 5-MeO-DMT product candidate, GH002, a proprietary injectable 5-MeO-DMT product candidate, and GH003, a proprietary intranasal 5-MeO-DMT product candidate.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">On March 29, 2021, GH Research PLC was incorporated under the laws of Ireland to become the ultimate holding company for GH Research Ireland Limited pursuant to a corporate reorganization, which is described in further detail in note 13 “Share capital and reserves”.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">These consolidated financial statements were presented to the board of directors and approved by them for issue on March 28, 2022.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"><span style="font-weight: bold;">2. Basis of preparation, significant judgments, and accounting policies</span></div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">Basis of preparation</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-style: italic; font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">Compliance with International Financial Reporting Standards</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The consolidated financial statements for the year ended December 31, 2021, have been prepared in accordance with International Financial Reporting Standards (IFRS) as issued by the International Accounting Standards Board (IASB). These consolidated financial statements are presented in U.S. dollar (“USD” or “$”), which is the Company’s functional currency and the Group’s presentation currency. The financial statements have been prepared under the historical cost convention.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The incorporation of GH Research PLC was accounted for as a capital reorganization applying the predecessor accounting method. Under predecessor accounting, the Group carries forward the predecessor carrying values of the net assets and liabilities assumed as previously reflected in the financial statements of GH Research Ireland Limited and the comparatives are presented on that basis. The financial information presented prior to the incorporation of GH Research PLC, including the comparative financial information for the years ended December 31, 2020 and 2019, relate solely to GH Research Ireland Limited.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The financial information presented in this report does not represent full statutory accounts as defined by the Companies Act 2014. The statutory accounts of GH Research PLC for the year ended December 31, 2021, are expected to be filed with the Companies Registration Office by November 26, 2022.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-style: italic; font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">New and amended IFRS standards</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">There are no new IFRS standards, amendments to standards or interpretations that are mandatory for the financial year beginning on January 1, 2021, that are relevant to the Group and that have had any impact on the consolidated financial statements. New standards, amendments to standards and interpretations that are not yet effective have been deemed by the Group as currently not relevant and are not listed here.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-style: italic; font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">Going concern basis</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">GH Research is a clinical-stage biopharmaceutical company developing innovative therapeutics. The Group is exposed to all risks inherent in establishing and developing its business, including the substantial uncertainty that current projects will succeed. Research and development expenses have been incurred from the start of the Group’s activities, generating negative cash flows from operating activities since formation.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Since its incorporation, the Group has funded its growth through capital increases. The Group has no bank loans or other debt outstanding as of December 31, 2021. As a result, the Group is not exposed to liquidity risk through requests for early repayment of loans.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">As of December 31, 2021, the Group’s cash and cash equivalents amounted to $276.8 million (2020: $5.9 million).</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The board of directors believes that the Group has sufficient financial resources available to cover its planned cash outflows for at least the next twelve months from the date of issuance of these consolidated financial statements. The Group, therefore, continues to adopt the going concern basis in preparing its consolidated financial statements.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-style: italic; font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">Share conversion and consolidation</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">On May 27, 2021, the Company effected the conversion of its Series A preferred shares and Series B preferred shares into ordinary shares and it effected a 2.50-to-one share consolidation of its outstanding shares (see note 13, “Share capital and reserves”). Accordingly, all share and per share amounts for all financial years presented in these consolidated financial statements and notes thereto have been adjusted retroactively, where applicable, to reflect this share consolidation.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">Use of estimates and judgments</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The preparation of the consolidated financial statements requires management to make judgements, estimates and assumptions that affect the application of accounting policies and the reported amounts of assets and liabilities, income and expense. Actual results may differ from these estimates.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">In preparing these consolidated financial statements, the significant judgements made by management in applying the Group’s accounting policies and the key sources of estimation uncertainty included those that applied to the financial statements of GH Research Ireland Limited for the year ended December 31, 2020 and 2019, and are as follows:</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; color: rgb(0, 0, 0); font-style: italic; font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">Functional currency</div> <div style="text-align: justify; color: rgb(0, 0, 0); font-size: 12pt; font-style: italic; font-weight: bold; font-family: 'Times New Roman';"> <span style="font-size: 10pt;"><br/> </span> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">As explained in this note and in note 3, the functional currency of the subsidiary, GH Research Ireland Limited, is euro. Judgment was applied in the determination that euro was the appropriate functional currency of the subsidiary. The principal consideration supporting this decision was made by reference to the current activities the subsidiary undertakes which is the execution of clinical trials for which the costs are primarily in euro. Judgment was also applied in the determination that the U.S. dollar is the functional currency of the parent company with the principal considerations being that most of the expenses incurred and all funding raised are in U.S. dollars.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; color: rgb(0, 0, 0); font-style: italic; font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">Share-based compensation expense</div> <div style="text-align: justify; color: rgb(0, 0, 0); font-size: 12pt; font-style: italic; font-weight: bold; font-family: 'Times New Roman';"> <span style="font-size: 10pt;"><br/> </span> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">As explained in note 15, the expected volatility assumption used was based on selected volatility determined by median values observed among other comparable public companies. Judgment was applied in the selection of comparable public companies and of the relevant period of observation used to determine the median values.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; color: rgb(0, 0, 0); font-style: italic; font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">Deferred tax balances and the valuation of tax operating losses</div> <div style="text-align: justify; color: rgb(0, 0, 0); font-size: 12pt; font-style: italic; font-weight: bold; font-family: 'Times New Roman';"> <span style="font-size: 10pt;"><br/> </span> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">During the period from incorporation of GH Research Ireland Limited to December 31, 2021, the Group has incurred losses, which are a potential benefit in the event that the Group reports a taxable profit in the future. In preparing these financial statements, the Group has assessed that the likelihood of a taxable profit is currently not sufficiently certain for these potential benefits to be recognized as a deferred tax asset. This assessment is based on the status of the research into the Group’s principal investigational product and the significant challenges that remain before operating profits can be assured (refer to note 8, “Deferred income taxes”).</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">Significant accounting policies</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">Consolidation</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The consolidated financial statements incorporate the financial statements of the Company and its subsidiary, GH Research Ireland Limited. Subsidiaries are all entities over which the Company has control. Control is achieved when the Company has power over an entity, is exposed to or has rights to variable returns from its involvement with the entity and has the ability to affect returns through its power over the entity. Subsidiaries are fully consolidated from the date on which control is transferred to the Company. They are deconsolidated from the date that control ceases. All intercompany transactions have been eliminated.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">Foreign currency translation</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The functional currency of the Company is the U.S. dollar given it is listed on NASDAQ and its fundraising activities are in U.S. dollars. The functional currency of its subsidiary, GH Research Ireland Limited, is euro due to its expenses being mainly incurred in euro. These consolidated financial statements are presented in U.S. dollar which is the Group’s presentation currency.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Items included in the financial statement of the Company’s subsidiary are measured using the currency of the primary economic environment in which the entity operates which is the euro.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Foreign currency transactions are translated into the functional currency using the exchange rates prevailing at the dates of the transactions. Monetary assets and liabilities denominated in foreign currencies are retranslated at the consolidated statement of financial position date. The subsidiary is holding a U.S. cash balance and, as a result of the accounting treatment, when it is translated to euro in the subsidiary accounts, it results in a foreign currency translation difference in the income statement. On consolidation, the subsidiary’s assets and liabilities in foreign currencies are retranslated and the resulting foreign currency difference goes through the foreign currency translation reserve.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Share capital issuances are translated into U.S. dollars at the exchange rate prevailing when the contractual commitment is made. Foreign currency differences can arise on translation where the cash inflows are received in a different period to the contractual commitment.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">Cash and cash equivalents</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Cash and cash equivalents represents cash held on bank current accounts and is carried at amortized cost.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">Property, plant and equipment</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Property, plant and equipment are recorded at cost and depreciated using the straight-line method over the estimated useful lives of the respective assets, which are as follows:</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <table border="0" cellpadding="0" cellspacing="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;"> <tr> <td style="width: 80%; vertical-align: top;"> </td> <td style="width: 20%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);"> <div style="text-align: center;">Estimated Useful Life</div> </td> </tr> <tr> <td style="width: 80%; vertical-align: top;"> <br/> </td> <td rowspan="1" style="width: 20%; vertical-align: top;"> <br/> </td> </tr> <tr> <td style="width: 80%; vertical-align: top; background-color: rgb(204, 238, 255);"> <div>IT equipment</div> </td> <td style="width: 20%; vertical-align: top; background-color: rgb(204, 238, 255);"> <div style="text-align: center;">3 years</div> </td> </tr> <tr> <td style="width: 80%; vertical-align: top;"> <div>Office equipment</div> </td> <td style="width: 20%; vertical-align: top;"> <div style="text-align: center;">3 years</div> </td> </tr> <tr> <td style="width: 80%; vertical-align: top; background-color: rgb(204, 238, 255);"> <div>Medical equipment</div> </td> <td style="width: 20%; vertical-align: top; background-color: rgb(204, 238, 255);"> <div style="text-align: center;">2 years</div> </td> </tr> </table> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">Trade payables and other current liabilities</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Trade payables and other current liabilities are recognized initially at fair value and subsequently measured at amortized cost.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">Share-based compensation expense</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The fair value of options granted under the share option plan is recognized as a share-based compensation expense with a corresponding increase in equity. The total expense is recognized over the vesting period, which is the period over which all of the specified vesting conditions are to be satisfied.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">Share capital and additional paid-in capital</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-style: italic; font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">Share capital</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Share capital represents the nominal value of outstanding shares (see note 13, “Share capital and reserves”).</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-style: italic; font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">Additional paid-in capital</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Amounts of contribution in excess of nominal value are accounted for as additional paid-in capital. Incremental costs directly attributable to equity transactions such as the issue of new capital shares are shown in equity as a deduction, net of tax, from the proceeds within additional paid-in capital. Transaction costs that relate to equity and non-equity transactions are allocated to those transactions using a basis of allocation that is rational and consistent with similar transactions. If the equity instruments are not subsequently issued, the transaction costs would be expensed.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">Leases and right-of-use assets</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The Group recognizes a right-of-use asset and a corresponding lease liability for all arrangements in which it is a lessee, except for leases with a term of 12 months or less (short-term leases) and low-value leases. For these short-term and low-value leases, the Group recognizes the lease payments as an operating expense on a straight-line basis over the term of the lease. Currently all of the Group’s lease arrangements comply with the criteria for exception.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">Research and development expenses</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Research and development expenses consist of costs incurred in performing research and development activities, including salaries, share-based compensation and benefits, travel, and external costs of outside vendors engaged to conduct clinical development activities, clinical trials, technical development activities and the cost to manufacture clinical trial materials.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Research expenditure is recognized as an expense in the year in which it is incurred. Internal development expenditure is capitalized only if it meets the recognition criteria of IAS 38 “Intangible Assets”. Where regulatory and other uncertainties are such that the criteria are not met the expenditure is recognized in the statement of comprehensive income. When certain criteria are met, the Group may capitalize and amortize on a straight-line basis over its estimated useful life, internal development expenditures. To date, the Group has not capitalized any R&D expenses.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">General and administrative expenses</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">General and administrative expenses relate to the administration of the Group including salaries, share-based compensation and benefits, travel and external costs including legal and professional fees.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">Current and deferred income tax</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The tax expense for the financial year comprises current and deferred tax. Tax is recognized in the income statement, except to the extent that it relates to items recognized in other comprehensive income or directly in equity. In this case the related tax is recognized in other comprehensive income or directly in equity, respectively.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The current income tax charge is calculated on the basis of the tax laws enacted or substantively enacted at the balance sheet date where the Group generates taxable income. Management periodically evaluates positions taken in tax returns with respect to situations in which applicable tax regulation is subject to interpretation. It establishes provisions where appropriate on the basis of amounts expected to be paid to the tax authorities.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Taxes on income are accrued in the same financial year as the revenues and expenses to which they relate. Current income tax assets and liabilities for the current financial year are measured at the amount expected to be recovered from or paid to the taxation authorities.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Deferred income tax assets are recognized only to the extent that it is probable that future taxable profit will be available against which the temporary differences or the unused tax losses can be utilized. Deferred income tax assets from tax credit carry-forwards are recognized to the extent that the national tax authority confirms the eligibility of such a claim and that the realization of the related tax benefit through future taxable profits is probable.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">Segment reporting</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Management considers the Group to have only a <span style="-sec-ix-hidden:Fact_ee8c8436541c4b3ab40fb017d1bff38c">single</span> segment: Research and Development (“R&D”). This is consistent with the way that information is reported internally within the Group for the purpose of allocating resources and assessing performance.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">Loss per share</div> <div><br/></div> <div style="font-family: 'Times New Roman'; font-size: 10pt;">Basic loss per share is calculated by dividing the net loss attributable to shareholders by the weighted average number of shares in issue during the year.</div> <div style="text-align: justify; font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">Basis of preparation</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-style: italic; font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">Compliance with International Financial Reporting Standards</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The consolidated financial statements for the year ended December 31, 2021, have been prepared in accordance with International Financial Reporting Standards (IFRS) as issued by the International Accounting Standards Board (IASB). These consolidated financial statements are presented in U.S. dollar (“USD” or “$”), which is the Company’s functional currency and the Group’s presentation currency. The financial statements have been prepared under the historical cost convention.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The incorporation of GH Research PLC was accounted for as a capital reorganization applying the predecessor accounting method. Under predecessor accounting, the Group carries forward the predecessor carrying values of the net assets and liabilities assumed as previously reflected in the financial statements of GH Research Ireland Limited and the comparatives are presented on that basis. The financial information presented prior to the incorporation of GH Research PLC, including the comparative financial information for the years ended December 31, 2020 and 2019, relate solely to GH Research Ireland Limited.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The financial information presented in this report does not represent full statutory accounts as defined by the Companies Act 2014. The statutory accounts of GH Research PLC for the year ended December 31, 2021, are expected to be filed with the Companies Registration Office by November 26, 2022.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-style: italic; font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">New and amended IFRS standards</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">There are no new IFRS standards, amendments to standards or interpretations that are mandatory for the financial year beginning on January 1, 2021, that are relevant to the Group and that have had any impact on the consolidated financial statements. New standards, amendments to standards and interpretations that are not yet effective have been deemed by the Group as currently not relevant and are not listed here.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-style: italic; font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">Going concern basis</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">GH Research is a clinical-stage biopharmaceutical company developing innovative therapeutics. The Group is exposed to all risks inherent in establishing and developing its business, including the substantial uncertainty that current projects will succeed. Research and development expenses have been incurred from the start of the Group’s activities, generating negative cash flows from operating activities since formation.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Since its incorporation, the Group has funded its growth through capital increases. The Group has no bank loans or other debt outstanding as of December 31, 2021. As a result, the Group is not exposed to liquidity risk through requests for early repayment of loans.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">As of December 31, 2021, the Group’s cash and cash equivalents amounted to $276.8 million (2020: $5.9 million).</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The board of directors believes that the Group has sufficient financial resources available to cover its planned cash outflows for at least the next twelve months from the date of issuance of these consolidated financial statements. The Group, therefore, continues to adopt the going concern basis in preparing its consolidated financial statements.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-style: italic; font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">Share conversion and consolidation</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">On May 27, 2021, the Company effected the conversion of its Series A preferred shares and Series B preferred shares into ordinary shares and it effected a 2.50-to-one share consolidation of its outstanding shares (see note 13, “Share capital and reserves”). Accordingly, all share and per share amounts for all financial years presented in these consolidated financial statements and notes thereto have been adjusted retroactively, where applicable, to reflect this share consolidation.</div>

276800000

5900000

2.50 <div style="text-align: justify; font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">Use of estimates and judgments</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The preparation of the consolidated financial statements requires management to make judgements, estimates and assumptions that affect the application of accounting policies and the reported amounts of assets and liabilities, income and expense. Actual results may differ from these estimates.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">In preparing these consolidated financial statements, the significant judgements made by management in applying the Group’s accounting policies and the key sources of estimation uncertainty included those that applied to the financial statements of GH Research Ireland Limited for the year ended December 31, 2020 and 2019, and are as follows:</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; color: rgb(0, 0, 0); font-style: italic; font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">Functional currency</div> <div style="text-align: justify; color: rgb(0, 0, 0); font-size: 12pt; font-style: italic; font-weight: bold; font-family: 'Times New Roman';"> <span style="font-size: 10pt;"><br/> </span> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">As explained in this note and in note 3, the functional currency of the subsidiary, GH Research Ireland Limited, is euro. Judgment was applied in the determination that euro was the appropriate functional currency of the subsidiary. The principal consideration supporting this decision was made by reference to the current activities the subsidiary undertakes which is the execution of clinical trials for which the costs are primarily in euro. Judgment was also applied in the determination that the U.S. dollar is the functional currency of the parent company with the principal considerations being that most of the expenses incurred and all funding raised are in U.S. dollars.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; color: rgb(0, 0, 0); font-style: italic; font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">Share-based compensation expense</div> <div style="text-align: justify; color: rgb(0, 0, 0); font-size: 12pt; font-style: italic; font-weight: bold; font-family: 'Times New Roman';"> <span style="font-size: 10pt;"><br/> </span> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">As explained in note 15, the expected volatility assumption used was based on selected volatility determined by median values observed among other comparable public companies. Judgment was applied in the selection of comparable public companies and of the relevant period of observation used to determine the median values.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; color: rgb(0, 0, 0); font-style: italic; font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">Deferred tax balances and the valuation of tax operating losses</div> <div style="text-align: justify; color: rgb(0, 0, 0); font-size: 12pt; font-style: italic; font-weight: bold; font-family: 'Times New Roman';"> <span style="font-size: 10pt;"><br/> </span> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">During the period from incorporation of GH Research Ireland Limited to December 31, 2021, the Group has incurred losses, which are a potential benefit in the event that the Group reports a taxable profit in the future. In preparing these financial statements, the Group has assessed that the likelihood of a taxable profit is currently not sufficiently certain for these potential benefits to be recognized as a deferred tax asset. This assessment is based on the status of the research into the Group’s principal investigational product and the significant challenges that remain before operating profits can be assured (refer to note 8, “Deferred income taxes”).</div> <div style="text-align: justify; font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">Consolidation</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The consolidated financial statements incorporate the financial statements of the Company and its subsidiary, GH Research Ireland Limited. Subsidiaries are all entities over which the Company has control. Control is achieved when the Company has power over an entity, is exposed to or has rights to variable returns from its involvement with the entity and has the ability to affect returns through its power over the entity. Subsidiaries are fully consolidated from the date on which control is transferred to the Company. They are deconsolidated from the date that control ceases. All intercompany transactions have been eliminated.</div>

<div style="text-align: justify; font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">Foreign currency translation</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The functional currency of the Company is the U.S. dollar given it is listed on NASDAQ and its fundraising activities are in U.S. dollars. The functional currency of its subsidiary, GH Research Ireland Limited, is euro due to its expenses being mainly incurred in euro. These consolidated financial statements are presented in U.S. dollar which is the Group’s presentation currency.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Items included in the financial statement of the Company’s subsidiary are measured using the currency of the primary economic environment in which the entity operates which is the euro.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Foreign currency transactions are translated into the functional currency using the exchange rates prevailing at the dates of the transactions. Monetary assets and liabilities denominated in foreign currencies are retranslated at the consolidated statement of financial position date. The subsidiary is holding a U.S. cash balance and, as a result of the accounting treatment, when it is translated to euro in the subsidiary accounts, it results in a foreign currency translation difference in the income statement. On consolidation, the subsidiary’s assets and liabilities in foreign currencies are retranslated and the resulting foreign currency difference goes through the foreign currency translation reserve.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Share capital issuances are translated into U.S. dollars at the exchange rate prevailing when the contractual commitment is made. Foreign currency differences can arise on translation where the cash inflows are received in a different period to the contractual commitment.</div>

<div style="text-align: justify; font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">Cash and cash equivalents</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Cash and cash equivalents represents cash held on bank current accounts and is carried at amortized cost.</div>

<div style="text-align: justify; font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">Property, plant and equipment</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Property, plant and equipment are recorded at cost and depreciated using the straight-line method over the estimated useful lives of the respective assets, which are as follows:</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <table border="0" cellpadding="0" cellspacing="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;"> <tr> <td style="width: 80%; vertical-align: top;"> </td> <td style="width: 20%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);"> <div style="text-align: center;">Estimated Useful Life</div> </td> </tr> <tr> <td style="width: 80%; vertical-align: top;"> <br/> </td> <td rowspan="1" style="width: 20%; vertical-align: top;"> <br/> </td> </tr> <tr> <td style="width: 80%; vertical-align: top; background-color: rgb(204, 238, 255);"> <div>IT equipment</div> </td> <td style="width: 20%; vertical-align: top; background-color: rgb(204, 238, 255);"> <div style="text-align: center;">3 years</div> </td> </tr> <tr> <td style="width: 80%; vertical-align: top;"> <div>Office equipment</div> </td> <td style="width: 20%; vertical-align: top;"> <div style="text-align: center;">3 years</div> </td> </tr> <tr> <td style="width: 80%; vertical-align: top; background-color: rgb(204, 238, 255);"> <div>Medical equipment</div> </td> <td style="width: 20%; vertical-align: top; background-color: rgb(204, 238, 255);"> <div style="text-align: center;">2 years</div> </td> </tr> </table>

<div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Property, plant and equipment are recorded at cost and depreciated using the straight-line method over the estimated useful lives of the respective assets, which are as follows:</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <table border="0" cellpadding="0" cellspacing="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;"> <tr> <td style="width: 80%; vertical-align: top;"> </td> <td style="width: 20%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);"> <div style="text-align: center;">Estimated Useful Life</div> </td> </tr> <tr> <td style="width: 80%; vertical-align: top;"> <br/> </td> <td rowspan="1" style="width: 20%; vertical-align: top;"> <br/> </td> </tr> <tr> <td style="width: 80%; vertical-align: top; background-color: rgb(204, 238, 255);"> <div>IT equipment</div> </td> <td style="width: 20%; vertical-align: top; background-color: rgb(204, 238, 255);"> <div style="text-align: center;">3 years</div> </td> </tr> <tr> <td style="width: 80%; vertical-align: top;"> <div>Office equipment</div> </td> <td style="width: 20%; vertical-align: top;"> <div style="text-align: center;">3 years</div> </td> </tr> <tr> <td style="width: 80%; vertical-align: top; background-color: rgb(204, 238, 255);"> <div>Medical equipment</div> </td> <td style="width: 20%; vertical-align: top; background-color: rgb(204, 238, 255);"> <div style="text-align: center;">2 years</div> </td> </tr> </table>

P3Y

P2Y

<div style="text-align: justify; font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">Trade payables and other current liabilities</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Trade payables and other current liabilities are recognized initially at fair value and subsequently measured at amortized cost.</div>

<div style="text-align: justify; font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">Share-based compensation expense</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The fair value of options granted under the share option plan is recognized as a share-based compensation expense with a corresponding increase in equity. The total expense is recognized over the vesting period, which is the period over which all of the specified vesting conditions are to be satisfied.</div>

<div style="text-align: justify; font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">Share capital and additional paid-in capital</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-style: italic; font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">Share capital</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Share capital represents the nominal value of outstanding shares (see note 13, “Share capital and reserves”).</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-style: italic; font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">Additional paid-in capital</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Amounts of contribution in excess of nominal value are accounted for as additional paid-in capital. Incremental costs directly attributable to equity transactions such as the issue of new capital shares are shown in equity as a deduction, net of tax, from the proceeds within additional paid-in capital. Transaction costs that relate to equity and non-equity transactions are allocated to those transactions using a basis of allocation that is rational and consistent with similar transactions. If the equity instruments are not subsequently issued, the transaction costs would be expensed.</div>

<div style="text-align: justify; font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">Leases and right-of-use assets</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The Group recognizes a right-of-use asset and a corresponding lease liability for all arrangements in which it is a lessee, except for leases with a term of 12 months or less (short-term leases) and low-value leases. For these short-term and low-value leases, the Group recognizes the lease payments as an operating expense on a straight-line basis over the term of the lease. Currently all of the Group’s lease arrangements comply with the criteria for exception.</div>

<div style="text-align: justify; font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">Research and development expenses</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Research and development expenses consist of costs incurred in performing research and development activities, including salaries, share-based compensation and benefits, travel, and external costs of outside vendors engaged to conduct clinical development activities, clinical trials, technical development activities and the cost to manufacture clinical trial materials.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Research expenditure is recognized as an expense in the year in which it is incurred. Internal development expenditure is capitalized only if it meets the recognition criteria of IAS 38 “Intangible Assets”. Where regulatory and other uncertainties are such that the criteria are not met the expenditure is recognized in the statement of comprehensive income. When certain criteria are met, the Group may capitalize and amortize on a straight-line basis over its estimated useful life, internal development expenditures. To date, the Group has not capitalized any R&D expenses.</div>

<div style="text-align: justify; font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">General and administrative expenses</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">General and administrative expenses relate to the administration of the Group including salaries, share-based compensation and benefits, travel and external costs including legal and professional fees.</div>

<div style="text-align: justify; font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">Current and deferred income tax</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The tax expense for the financial year comprises current and deferred tax. Tax is recognized in the income statement, except to the extent that it relates to items recognized in other comprehensive income or directly in equity. In this case the related tax is recognized in other comprehensive income or directly in equity, respectively.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The current income tax charge is calculated on the basis of the tax laws enacted or substantively enacted at the balance sheet date where the Group generates taxable income. Management periodically evaluates positions taken in tax returns with respect to situations in which applicable tax regulation is subject to interpretation. It establishes provisions where appropriate on the basis of amounts expected to be paid to the tax authorities.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Taxes on income are accrued in the same financial year as the revenues and expenses to which they relate. Current income tax assets and liabilities for the current financial year are measured at the amount expected to be recovered from or paid to the taxation authorities.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Deferred income tax assets are recognized only to the extent that it is probable that future taxable profit will be available against which the temporary differences or the unused tax losses can be utilized. Deferred income tax assets from tax credit carry-forwards are recognized to the extent that the national tax authority confirms the eligibility of such a claim and that the realization of the related tax benefit through future taxable profits is probable.</div>

<div style="text-align: justify; font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">Segment reporting</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Management considers the Group to have only a <span style="-sec-ix-hidden:Fact_ee8c8436541c4b3ab40fb017d1bff38c">single</span> segment: Research and Development (“R&D”). This is consistent with the way that information is reported internally within the Group for the purpose of allocating resources and assessing performance.</div>

<div style="font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">Loss per share</div> <div><br/></div> <div style="font-family: 'Times New Roman'; font-size: 10pt;">Basic loss per share is calculated by dividing the net loss attributable to shareholders by the weighted average number of shares in issue during the year.</div>

<div style="font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">3. Financial risk management</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">Financial risk factors</div> <div style="font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;"> <br/> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The board of directors currently reviews the Group’s cash forecast and liquidity requirements. It considers that other financial risks are currently inconsequential to the Group’s activities and outlook. More sophisticated tools for financial risk management will be implemented once such risks are deemed consequential.</div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;"> <br/> </div> <div style="font-style: italic; font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">Foreign exchange risk</div> <div style="font-style: italic; font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;"> <br/> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The Group operates internationally and is exposed to foreign exchange risk arising from various currency exposures, primarily with respect to the U.S. dollar, euro and pounds sterling. Transaction exposure arises because the amount of local currency paid or received in transactions denominated in foreign currencies may vary due to changes in exchange rates. Foreign exchange risk arises from:</div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;"> <br/> </div> <table cellpadding="0" cellspacing="0" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;"> <tr> <td style="width: 18pt; vertical-align: top; font-weight: bold;">-</td> <td style="width: auto; vertical-align: top; text-align: justify;"> <div>forecast expenses denominated in a currency other than the entity’s functional currency; and</div> </td> </tr> </table> <table cellpadding="0" cellspacing="0" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;"> <tr> <td style="width: 18pt; vertical-align: top; font-weight: bold;">-</td> <td style="width: auto; vertical-align: top; text-align: justify;"> <div>recognized assets and liabilities denominated in a currency other than the entity’s functional currency.</div> </td> </tr> </table> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> <br/> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The Group’s cash and cash equivalents are denominated in the following currencies:</div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;"> <br/> </div> <table cellpadding="0" cellspacing="0" class="cfttable" style="font-family: 'Times New Roman'; font-size: 10pt; text-align: left; color: #000000; width: 100%;"> <tr> <td style="vertical-align: top; font-weight: bold;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold;" valign="bottom"> </td> <td colspan="2" style="vertical-align: top;" valign="bottom"> <div style="text-align: center; font-weight: bold;"> 2021</div> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold;" valign="bottom"> </td> <td colspan="2" style="vertical-align: top;" valign="bottom"> <div style="text-align: center; font-weight: bold;">2021</div> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold;" valign="bottom"> </td> <td colspan="2" style="vertical-align: top;" valign="bottom"> <div style="text-align: center; font-weight: bold;">2020</div> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold;" valign="bottom"> </td> <td colspan="2" style="vertical-align: top;" valign="bottom"> <div style="text-align: center; font-weight: bold;">2020</div> </td> </tr> <tr> <td style="vertical-align: top; font-weight: bold; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="2" style="vertical-align: middle; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0); text-align: center;"> <div>Local</div> <div>Currency</div> <div>’000</div> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="2" rowspan="1" style="vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); text-align: center;"> <div style="font-weight: bold;">$’000</div> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="2" style="vertical-align: middle; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0); text-align: center;"> <div>Local</div> <div>Currency</div> <div>’000</div> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="2" rowspan="1" style="vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); text-align: center;"> <div style="font-weight: bold;">$’000</div> </td> </tr> <tr> <td style="vertical-align: top; width: 52.53%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>In USD</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>276,447</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>276,447</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>—</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>—</div> </td> </tr> <tr> <td style="vertical-align: top; width: 52.53%; padding-bottom: 2px;" valign="bottom"> <div>In Euro</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; padding-bottom: 2px;" valign="bottom"> <div>290</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; padding-bottom: 2px; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div>329</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; padding-bottom: 2px; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; padding-bottom: 2px;" valign="bottom"> <div>4,826</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; padding-bottom: 2px; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div>5,895</div> </td> </tr> <tr> <td style="vertical-align: top; width: 52.53%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="font-weight: bold;">276,776</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); font-weight: bold; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); font-weight: bold;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); font-weight: bold;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255); font-weight: bold;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); font-weight: bold; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); font-weight: bold;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); font-weight: bold;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="font-weight: bold;">5,895</div> </td> </tr> </table> <div style="font-family: 'Times New Roman'; font-size: 10pt;"><br/> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The Group is exposed to foreign exchange risk in its subsidiary as its functional currency is euro. The subsidiary holds significant cash deposits denominated in U.S. dollar. Accordingly, future changes in the exchange rates of euro and the U.S. dollar will expose the Group to currency gains or losses that will impact the reported amounts of assets, liabilities, income and expenses and the impact could be material.</div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;"> <br/> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">For the year ended December 31, 2021, the Group recognized a foreign exchange gain of $5.9 million (2020: $<span style="-sec-ix-hidden:Fact_0eab925aadcd4d25ba550af9ca9def82">nil</span>). The foreign exchange gain was primarily related to the U.S. dollar cash holding of its subsidiary and the associated strengthening of the U.S. dollar compared to euro during the year. While the Group benefited from changes in foreign exchange rates in 2021, it is possible that foreign exchange losses could occur. Any occurrences of foreign exchange losses would negatively affect the Group and the effect could be material.<br/> <br/> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The Group does not believe there is currently a need to enter into specific contracts to reduce the exposure to changes in foreign exchange rates, such as by entering into options or forward contracts. The Group may in the future consider using options or forward contracts to manage currency transaction exposures.</div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;"> <br/> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">At December 31, 2021, if the U.S. dollar had weakened / strengthened by 10% against the euro with all other variables held constant, the loss before tax for the year would have been $10 million higher / lower, mainly related to the translation of cash held in U.S. dollar in the Company’s subsidiary, GH Research Ireland Limited, whose functional currency is euro as explained in note 2, “Basis of preparation, significant judgments, and accounting policies”(2020: $<span style="-sec-ix-hidden:Fact_5e8973ba9c054814b2bd17562c88dc63">nil</span> higher / lower).</div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;"> <br/> </div> <div style="font-style: italic; font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">Credit risk</div> <div style="font-style: italic; font-family: 'Times New Roman'; font-size: 10pt;"> <br/> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The Group is not currently exposed to significant credit risk except on its cash and cash equivalents. The Group’s cash balance is maintained with well established, highly rated financial institutions. As of December 31, 2021, the cash balances are held at one bank that has S&P’s credit rating of BBB+. The Group does not invest in equity instruments or derivatives.</div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;"> <br/> </div> <div style="font-style: italic; font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">Liquidity risk</div> <div style="font-style: italic; font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;"> <br/> </div> <div style="font-family: 'Times New Roman'; font-size: 10pt;">Liquidity risk is the risk that the Group may not be able to generate sufficient cash resources to settle its obligations in full as they fall due or can do so only on terms that are materially disadvantageous. Prudent liquidity risk management implies maintaining sufficient cash to cover working capital requirements. Cash is monitored by the Group’s management.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> <br/> </div> <div style="font-family: 'Times New Roman'; font-size: 10pt;">Funding and liquidity risks are reviewed regularly by the board of directors and management. The Group funds its capital requirements through capital raising.<br/> <br/> </div> <div style="font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">Capital management</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> <br/> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The Group considers equity as equivalent to the IFRS equity on the balance sheet (including share capital, additional paid-in capital and all other equity reserves attributable to the owners of the Company). The Group has no interest-bearing debt.</div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;"> <br/> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The Group’s objectives when managing capital are to safeguard the Group’s ability to continue as a going concern and to provide returns to its shareholders through advancing our investigational pharmaceutical product candidates towards regulatory approval.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">Fair value estimation</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The carrying amount is considered to be identical to the fair value for the following financial assets and liabilities:</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <table cellpadding="0" cellspacing="0" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;"> <tr> <td style="width: 18pt;"><br/> </td> <td style="width: 27pt; vertical-align: top;">-</td> <td style="width: auto; vertical-align: top; text-align: justify;"> <div>Cash and cash equivalents</div> </td> </tr> </table> <table cellpadding="0" cellspacing="0" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;"> <tr> <td style="width: 18pt;"><br/> </td> <td style="width: 27pt; vertical-align: top;">-</td> <td style="width: auto; vertical-align: top; text-align: justify;"> <div>Other current assets</div> </td> </tr> </table> <table cellpadding="0" cellspacing="0" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;"> <tr> <td style="width: 18pt;"><br/> </td> <td style="width: 27pt; vertical-align: top;">-</td> <td style="width: auto; vertical-align: top; text-align: justify;"> <div>Trade payables and other current liabilities</div> </td> </tr> </table> <div style="font-family: 'Times New Roman'; font-size: 10pt;"><br/> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">There were no significant changes in the business or economic circumstances that affect the fair value of the Group’s financial assets and financial liabilities.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Fair values must be estimated on an ongoing basis with regard to awards under the Share Option Plan. The approach to valuation follows the grant date fair value principle and the key input factors are described for the share-based compensation awards in note 15, “Share-based compensation”.</div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The Group’s cash and cash equivalents are denominated in the following currencies:</div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;"> <br/> </div> <table cellpadding="0" cellspacing="0" class="cfttable" style="font-family: 'Times New Roman'; font-size: 10pt; text-align: left; color: #000000; width: 100%;"> <tr> <td style="vertical-align: top; font-weight: bold;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold;" valign="bottom"> </td> <td colspan="2" style="vertical-align: top;" valign="bottom"> <div style="text-align: center; font-weight: bold;"> 2021</div> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold;" valign="bottom"> </td> <td colspan="2" style="vertical-align: top;" valign="bottom"> <div style="text-align: center; font-weight: bold;">2021</div> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold;" valign="bottom"> </td> <td colspan="2" style="vertical-align: top;" valign="bottom"> <div style="text-align: center; font-weight: bold;">2020</div> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold;" valign="bottom"> </td> <td colspan="2" style="vertical-align: top;" valign="bottom"> <div style="text-align: center; font-weight: bold;">2020</div> </td> </tr> <tr> <td style="vertical-align: top; font-weight: bold; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="2" style="vertical-align: middle; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0); text-align: center;"> <div>Local</div> <div>Currency</div> <div>’000</div> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="2" rowspan="1" style="vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); text-align: center;"> <div style="font-weight: bold;">$’000</div> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="2" style="vertical-align: middle; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0); text-align: center;"> <div>Local</div> <div>Currency</div> <div>’000</div> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="2" rowspan="1" style="vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); text-align: center;"> <div style="font-weight: bold;">$’000</div> </td> </tr> <tr> <td style="vertical-align: top; width: 52.53%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>In USD</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>276,447</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>276,447</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>—</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>—</div> </td> </tr> <tr> <td style="vertical-align: top; width: 52.53%; padding-bottom: 2px;" valign="bottom"> <div>In Euro</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; padding-bottom: 2px;" valign="bottom"> <div>290</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; padding-bottom: 2px; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div>329</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; padding-bottom: 2px; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; padding-bottom: 2px;" valign="bottom"> <div>4,826</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; padding-bottom: 2px; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div>5,895</div> </td> </tr> <tr> <td style="vertical-align: top; width: 52.53%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="font-weight: bold;">276,776</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); font-weight: bold; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); font-weight: bold;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); font-weight: bold;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255); font-weight: bold;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); font-weight: bold; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); font-weight: bold;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); font-weight: bold;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="font-weight: bold;">5,895</div> </td> </tr> </table>

276447000

290000

329000

4826000

5895000

276776000

5895000

5900000

-10000000

<div style="font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">4. Expenses by nature</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The following table provides the consolidated statement of comprehensive income classification of our expense by nature:</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <table cellpadding="0" cellspacing="0" class="cfttable" style="font-family: 'Times New Roman'; font-size: 10pt; text-align: left; color: rgb(0, 0, 0); width: 100%;"> <tr> <td style="vertical-align: top; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="10" style="vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="text-align: center; font-weight: bold;">Year ended</div> <div style="text-align: center; font-weight: bold;">December 31,</div> </td> </tr> <tr> <td style="vertical-align: top;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom;" valign="bottom"> </td> <td colspan="2" style="vertical-align: top;" valign="bottom"> <div style="text-align: center; font-weight: bold;"> 2021<br/> </div> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold;" valign="bottom"> </td> <td colspan="2" style="vertical-align: top;" valign="bottom"> <div style="text-align: center; font-weight: bold;">2020<br/> </div> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold;" valign="bottom"> </td> <td colspan="2" style="vertical-align: top;" valign="bottom"> <div style="text-align: center; font-weight: bold;">2019<br/> </div> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="2" rowspan="1" style="vertical-align: bottom; width: 10.13%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold; text-align: center;">$’000</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="2" rowspan="1" style="vertical-align: bottom; width: 10.13%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold; text-align: center;">$’000</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="2" rowspan="1" style="vertical-align: bottom; width: 10.13%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold; text-align: center;">$’000</div> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt; font-weight: bold;"><span style="text-decoration: underline;">Research and development</span></div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%;" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">External costs <sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)</sup></div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%;" valign="bottom"> <div>7,134</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%;" valign="bottom"> <div>338</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%;" valign="bottom"> <div>296</div> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%; padding-bottom: 2px; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Employee expenses <sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(2)</sup></div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; padding-bottom: 2px; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> <div>1,419</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> <div>—</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> <div>—</div> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%; padding-bottom: 2px;" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt; font-weight: bold;">Total research and development expenses</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold;">8,553</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold;">338</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold;">296</div> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%;" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt; font-weight: bold;"><span style="text-decoration: underline;">General and administrative</span></div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%;" valign="bottom"> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">External costs <sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)</sup></div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>5,623</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>103</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>14</div> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%; padding-bottom: 2px;" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Employee expenses <sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(2)</sup></div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div>924</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div>5</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div>—</div> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%; padding-bottom: 2px; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt; font-weight: bold;">Total general and administrative expenses</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; padding-bottom: 2px; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> <div style="font-weight: bold;">6,547</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); font-weight: bold; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); font-weight: bold; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); font-weight: bold; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> <div style="font-weight: bold;">108</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); font-weight: bold; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); font-weight: bold; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); font-weight: bold; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> <div style="font-weight: bold;">14</div> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%; padding-bottom: 4px;" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt; font-weight: bold;">Total operating expenses</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; padding-bottom: 4px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold;">15,100</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 4px double rgb(0, 0, 0); font-weight: bold; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 4px double rgb(0, 0, 0); font-weight: bold;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 4px double rgb(0, 0, 0); font-weight: bold;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold;">446</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 4px double rgb(0, 0, 0); font-weight: bold; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 4px double rgb(0, 0, 0); font-weight: bold;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 4px double rgb(0, 0, 0); font-weight: bold;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold;">310</div> </td> </tr> </table> <div style="font-family: 'Times New Roman'; font-size: 10pt;"><br/> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;"><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1) </sup>Includes depreciation expense (see note 10, “Property, plant and equipment”).</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;"><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(2) </sup>Includes share-based compensation expense (see note 15, “Share-based compensation”).</div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;"> <br/> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The increase in research and development expenses in the year ended December 31, 2021 was primarily due to increased external costs relating to our technical development and clinical trials and employee expenses relating to the hiring of personnel in our research and development team to support the requirements of increased clinical activities. The increase in research and development expenses in the year ended December 31, 2020 was primarily due to increased external costs relating to our clinical trials.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The increase in general and administrative expenses for the year ended December 31, 2021 was primarily due to costs incurred in preparation for our initial public offering, as well as subsequent higher professional and compliance fees associated with being a public company, and increased employee expenses in our general and administrative functions to support our growth initiatives. The increase in general and administrative expenses for the year ended December 31, 2020 was primarily due to increased external costs relating to professional fees.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">Foreign currency translation differences</div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;"> <br/> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Foreign currency translation differences of $5.9 million for the year ended December 31, 2021 (2020: $<span style="-sec-ix-hidden:Fact_c94e93de8d324e058d4a350ea106d299">nil</span>, 2019: $<span style="-sec-ix-hidden:Fact_d28ea85dd508470fab7db547e2475b17">nil</span>) consist primarily of gains related to the translation of U.S. dollar cash balance into euro in the accounts of the Company’s subsidiary, GH Research Ireland Limited, whose functional currency is euro as explained in note 2, “Basis of preparation, significant judgments, and accounting policies”.</div>

<div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The following table provides the consolidated statement of comprehensive income classification of our expense by nature:</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <table cellpadding="0" cellspacing="0" class="cfttable" style="font-family: 'Times New Roman'; font-size: 10pt; text-align: left; color: rgb(0, 0, 0); width: 100%;"> <tr> <td style="vertical-align: top; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="10" style="vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="text-align: center; font-weight: bold;">Year ended</div> <div style="text-align: center; font-weight: bold;">December 31,</div> </td> </tr> <tr> <td style="vertical-align: top;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom;" valign="bottom"> </td> <td colspan="2" style="vertical-align: top;" valign="bottom"> <div style="text-align: center; font-weight: bold;"> 2021<br/> </div> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold;" valign="bottom"> </td> <td colspan="2" style="vertical-align: top;" valign="bottom"> <div style="text-align: center; font-weight: bold;">2020<br/> </div> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold;" valign="bottom"> </td> <td colspan="2" style="vertical-align: top;" valign="bottom"> <div style="text-align: center; font-weight: bold;">2019<br/> </div> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="2" rowspan="1" style="vertical-align: bottom; width: 10.13%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold; text-align: center;">$’000</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="2" rowspan="1" style="vertical-align: bottom; width: 10.13%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold; text-align: center;">$’000</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="2" rowspan="1" style="vertical-align: bottom; width: 10.13%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold; text-align: center;">$’000</div> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt; font-weight: bold;"><span style="text-decoration: underline;">Research and development</span></div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%;" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">External costs <sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)</sup></div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%;" valign="bottom"> <div>7,134</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%;" valign="bottom"> <div>338</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%;" valign="bottom"> <div>296</div> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%; padding-bottom: 2px; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Employee expenses <sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(2)</sup></div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; padding-bottom: 2px; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> <div>1,419</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> <div>—</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> <div>—</div> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%; padding-bottom: 2px;" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt; font-weight: bold;">Total research and development expenses</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold;">8,553</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold;">338</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold;">296</div> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%;" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt; font-weight: bold;"><span style="text-decoration: underline;">General and administrative</span></div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%;" valign="bottom"> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">External costs <sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)</sup></div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>5,623</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>103</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>14</div> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%; padding-bottom: 2px;" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Employee expenses <sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(2)</sup></div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div>924</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div>5</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div>—</div> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%; padding-bottom: 2px; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt; font-weight: bold;">Total general and administrative expenses</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; padding-bottom: 2px; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> <div style="font-weight: bold;">6,547</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); font-weight: bold; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); font-weight: bold; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); font-weight: bold; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> <div style="font-weight: bold;">108</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); font-weight: bold; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); font-weight: bold; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); font-weight: bold; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> <div style="font-weight: bold;">14</div> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%; padding-bottom: 4px;" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt; font-weight: bold;">Total operating expenses</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; padding-bottom: 4px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold;">15,100</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 4px double rgb(0, 0, 0); font-weight: bold; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 4px double rgb(0, 0, 0); font-weight: bold;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 4px double rgb(0, 0, 0); font-weight: bold;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold;">446</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 4px double rgb(0, 0, 0); font-weight: bold; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 4px double rgb(0, 0, 0); font-weight: bold;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 4px double rgb(0, 0, 0); font-weight: bold;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold;">310</div> </td> </tr> </table> <div style="font-family: 'Times New Roman'; font-size: 10pt;"><br/> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;"><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1) </sup>Includes depreciation expense (see note 10, “Property, plant and equipment”).</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;"><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(2) </sup>Includes share-based compensation expense (see note 15, “Share-based compensation”).</div> 7134000 338000 296000 1419000 0 0

8553000

338000

296000

5623000 103000 14000 924000 5000 0

6547000

108000

14000

15100000

446000

310000

5900000

<div style="font-family: 'Times New Roman'; font-size: 10pt;"><span style="font-weight: bold;">5. Employee expenses</span></div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <table cellpadding="0" cellspacing="0" class="cfttable" style="font-family: 'Times New Roman'; font-size: 10pt; text-align: left; color: #000000; width: 100%;"> <tr> <td style="vertical-align: top; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="10" style="vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="text-align: center; font-weight: bold;">Year ended</div> <div style="text-align: center; font-weight: bold;">December 31,</div> </td> </tr> <tr> <td style="vertical-align: top;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom;" valign="bottom"> </td> <td colspan="2" style="vertical-align: top;" valign="bottom"> <div style="text-align: center; font-weight: bold;"> 2021<br/> </div> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold;" valign="bottom"> </td> <td colspan="2" style="vertical-align: top;" valign="bottom"> <div style="text-align: center; font-weight: bold;">2020</div> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold;" valign="bottom"> </td> <td colspan="2" style="vertical-align: top;" valign="bottom"> <div style="text-align: center; font-weight: bold;">2019<br/> </div> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="2" rowspan="1" style="vertical-align: bottom; width: 10.13%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold; text-align: center;">$’000</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="2" rowspan="1" style="vertical-align: bottom; width: 10.13%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold; text-align: center;">$’000</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="2" rowspan="1" style="vertical-align: bottom; width: 10.13%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold; text-align: center;">$’000</div> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Salary and related expenses</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>1,862</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>4</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>—</div> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%;" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Social security costs</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%;" valign="bottom"> <div>115</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%;" valign="bottom"> <div>1</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%;" valign="bottom"> <div>—</div> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%; padding-bottom: 2px; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Shared based compensation expense</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; padding-bottom: 2px; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> <div>366</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> <div>—</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> <div>—</div> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold;">2,343</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold;">5</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold;">—</div> </td> </tr> </table> <div style="font-family: 'Times New Roman'; font-size: 10pt;"><br/> </div> <div style="text-align: justify; font-size: 12pt; font-family: 'Times New Roman';"><span style="font-size: 10pt;">This increase is primarily due to the increased hiring of personnel across our functions to support the requirements of increased clinical activities and becoming a public company. A shared based compensation expense of $366 thousand has been recognized for the year ended December 31, 2021 relating to the Share Option Plan as set out in note 15.</span></div> <table cellpadding="0" cellspacing="0" class="cfttable" style="font-family: 'Times New Roman'; font-size: 10pt; text-align: left; color: #000000; width: 100%;"> <tr> <td style="vertical-align: top; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="10" style="vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="text-align: center; font-weight: bold;">Year ended</div> <div style="text-align: center; font-weight: bold;">December 31,</div> </td> </tr> <tr> <td style="vertical-align: top;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom;" valign="bottom"> </td> <td colspan="2" style="vertical-align: top;" valign="bottom"> <div style="text-align: center; font-weight: bold;"> 2021<br/> </div> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold;" valign="bottom"> </td> <td colspan="2" style="vertical-align: top;" valign="bottom"> <div style="text-align: center; font-weight: bold;">2020</div> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold;" valign="bottom"> </td> <td colspan="2" style="vertical-align: top;" valign="bottom"> <div style="text-align: center; font-weight: bold;">2019<br/> </div> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="2" rowspan="1" style="vertical-align: bottom; width: 10.13%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold; text-align: center;">$’000</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="2" rowspan="1" style="vertical-align: bottom; width: 10.13%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold; text-align: center;">$’000</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="2" rowspan="1" style="vertical-align: bottom; width: 10.13%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold; text-align: center;">$’000</div> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Salary and related expenses</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>1,862</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>4</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>—</div> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%;" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Social security costs</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%;" valign="bottom"> <div>115</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%;" valign="bottom"> <div>1</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%;" valign="bottom"> <div>—</div> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%; padding-bottom: 2px; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Shared based compensation expense</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; padding-bottom: 2px; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> <div>366</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> <div>—</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> <div>—</div> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold;">2,343</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold;">5</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold;">—</div> </td> </tr> </table>

1862000

4000

115000

1000

366000

2343000

5000

366000

<div style="font-family: 'Times New Roman'; font-size: 10pt;"><span style="font-weight: bold;">6. Leases</span></div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The Group incurred lease expenses for short-term leases as follows:</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <table cellpadding="0" cellspacing="0" class="cfttable" style="font-family: 'Times New Roman'; font-size: 10pt; text-align: left; color: #000000; width: 100%;"> <tr> <td style="vertical-align: top; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="10" style="vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-weight: bold;" valign="bottom"> <div style="text-align: center;">Year ended</div> <div style="text-align: center;">December 31,</div> </td> </tr> <tr> <td style="vertical-align: top;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom;" valign="bottom"> </td> <td colspan="2" style="vertical-align: top;" valign="bottom"> <div style="text-align: center; font-weight: bold;"> 2021<br/> </div> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold;" valign="bottom"> </td> <td colspan="2" style="vertical-align: top;" valign="bottom"> <div style="text-align: center; font-weight: bold;">2020<br/> </div> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold;" valign="bottom"> </td> <td colspan="2" style="vertical-align: top;" valign="bottom"> <div style="text-align: center; font-weight: bold;">2019<br/> </div> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="2" rowspan="1" style="vertical-align: bottom; width: 10.13%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold; text-align: center;">$’000</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="2" rowspan="1" style="vertical-align: bottom; width: 10.13%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold; text-align: center;">$’000</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="2" rowspan="1" style="vertical-align: bottom; width: 10.13%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold; text-align: center;">$’000</div> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Lease expenses for short-term leases</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>76</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>5</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>—</div> </td> </tr> </table>

<div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The Group incurred lease expenses for short-term leases as follows:</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <table cellpadding="0" cellspacing="0" class="cfttable" style="font-family: 'Times New Roman'; font-size: 10pt; text-align: left; color: #000000; width: 100%;"> <tr> <td style="vertical-align: top; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="10" style="vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-weight: bold;" valign="bottom"> <div style="text-align: center;">Year ended</div> <div style="text-align: center;">December 31,</div> </td> </tr> <tr> <td style="vertical-align: top;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom;" valign="bottom"> </td> <td colspan="2" style="vertical-align: top;" valign="bottom"> <div style="text-align: center; font-weight: bold;"> 2021<br/> </div> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold;" valign="bottom"> </td> <td colspan="2" style="vertical-align: top;" valign="bottom"> <div style="text-align: center; font-weight: bold;">2020<br/> </div> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold;" valign="bottom"> </td> <td colspan="2" style="vertical-align: top;" valign="bottom"> <div style="text-align: center; font-weight: bold;">2019<br/> </div> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="2" rowspan="1" style="vertical-align: bottom; width: 10.13%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold; text-align: center;">$’000</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="2" rowspan="1" style="vertical-align: bottom; width: 10.13%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold; text-align: center;">$’000</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="2" rowspan="1" style="vertical-align: bottom; width: 10.13%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold; text-align: center;">$’000</div> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Lease expenses for short-term leases</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>76</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>5</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>—</div> </td> </tr> </table> 76000 5000 0

<div style="font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">7. Income tax</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The Group’s expected tax charge/(credit) of $<span style="-sec-ix-hidden:Fact_148c5d241cbd43e4b86db5808d2ff08e"><span style="-sec-ix-hidden:Fact_3561f88569e34e2eae760ba5cff27e9b"><span style="-sec-ix-hidden:Fact_7a20788c0080488ca9d8f3f21994e720">nil</span></span></span> for each year is based on the applicable tax rate in Ireland and reconciles to the actual tax charge/(credit) as follows:</div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;"> <br/> </div> <table cellpadding="0" cellspacing="0" class="cfttable" style="font-family: 'Times New Roman'; font-size: 10pt; text-align: left; color: #000000; width: 100%;"> <tr> <td style="vertical-align: top; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="font-weight: bold; vertical-align: bottom; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="10" style="vertical-align: top; font-weight: bold; border-bottom: #000000 solid 2px;" valign="bottom"> <div style="text-align: center;">Year ended</div> <div style="text-align: center;">December 31,</div> </td> <td colspan="1" style="font-weight: bold; text-align: left; vertical-align: bottom; padding-bottom: 2px; white-space: nowrap;" valign="bottom"> </td> </tr> <tr> <td style="vertical-align: top;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom;" valign="bottom"> </td> <td colspan="2" style="vertical-align: top;" valign="bottom"> <div style="text-align: center; font-weight: bold;">2021<br/> </div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom;" valign="bottom"> </td> <td colspan="2" style="vertical-align: top;" valign="bottom"> <div style="text-align: center; font-weight: bold;">2020<br/> </div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom;" valign="bottom"> </td> <td colspan="2" style="vertical-align: top;" valign="bottom"> <div style="text-align: center; font-weight: bold;">2019<br/> </div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; white-space: nowrap;" valign="bottom"> </td> </tr> <tr> <td style="vertical-align: top; width: 64%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" rowspan="1" style="vertical-align: bottom; width: 1%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="2" rowspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold; text-align: center;">$’000</div> </td> <td colspan="1" rowspan="1" style="text-align: center; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" rowspan="1" style="vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); text-align: center;" valign="bottom"> </td> <td colspan="2" rowspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold; text-align: center;">$’000</div> </td> <td colspan="1" rowspan="1" style="text-align: center; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" rowspan="1" style="vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); text-align: center;" valign="bottom"> </td> <td colspan="2" rowspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold; text-align: center;">$’000</div> </td> <td colspan="1" rowspan="1" style="text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px; white-space: nowrap;" valign="bottom"> </td> </tr> <tr> <td style="vertical-align: top; width: 64%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt; font-style: normal; font-weight: bold;">Loss before tax</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="font-weight: bold;">9,202</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); font-weight: bold; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); font-weight: bold;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); font-weight: bold;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="font-weight: bold;">446</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); font-weight: bold; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); font-weight: bold;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); font-weight: bold;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="font-weight: bold;">310</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> </tr> <tr> <td style="vertical-align: top; width: 64%;" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Tax credit calculated at the domestic tax rate <span style="text-indent: 0pt;">12.5</span>%</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%;" valign="bottom"> <div>(1,150</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; white-space: nowrap;" valign="bottom"> <div>)</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%;" valign="bottom"> <div>(56</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; white-space: nowrap;" valign="bottom"> <div>)</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%;" valign="bottom"> <div>(39</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; white-space: nowrap;" valign="bottom"> <div>)</div> </td> </tr> <tr> <td style="vertical-align: top; width: 64%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Tax effects of:</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> </tr> <tr> <td style="vertical-align: top; width: 64%; padding-bottom: 2px;" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Losses for which no deferred tax asset was recognized</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div>1,150</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div>56</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div>39</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px; white-space: nowrap;" valign="bottom"> </td> </tr> <tr> <td style="vertical-align: top; width: 64%; background-color: rgb(204, 238, 255); padding-bottom: 4px;" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Tax charge/(credit)</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); padding-bottom: 4px;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255); border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> <div>—</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); border-bottom: 4px double rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255); border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> <div>—</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); border-bottom: 4px double rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255); border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> <div>—</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); padding-bottom: 4px; white-space: nowrap;" valign="bottom"> </td> </tr> </table> <div style="font-family: 'Times New Roman'; font-size: 10pt;"><br/> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">No current tax charge was recognized in the years ended December 31, 2021, 2020 and 2019, respectively, as no amount is expected to be payable or recoverable on the taxable results for those years.</div>

<div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The Group’s expected tax charge/(credit) of $<span style="-sec-ix-hidden:Fact_148c5d241cbd43e4b86db5808d2ff08e"><span style="-sec-ix-hidden:Fact_3561f88569e34e2eae760ba5cff27e9b"><span style="-sec-ix-hidden:Fact_7a20788c0080488ca9d8f3f21994e720">nil</span></span></span> for each year is based on the applicable tax rate in Ireland and reconciles to the actual tax charge/(credit) as follows:</div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;"> <br/> </div> <table cellpadding="0" cellspacing="0" class="cfttable" style="font-family: 'Times New Roman'; font-size: 10pt; text-align: left; color: #000000; width: 100%;"> <tr> <td style="vertical-align: top; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="font-weight: bold; vertical-align: bottom; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="10" style="vertical-align: top; font-weight: bold; border-bottom: #000000 solid 2px;" valign="bottom"> <div style="text-align: center;">Year ended</div> <div style="text-align: center;">December 31,</div> </td> <td colspan="1" style="font-weight: bold; text-align: left; vertical-align: bottom; padding-bottom: 2px; white-space: nowrap;" valign="bottom"> </td> </tr> <tr> <td style="vertical-align: top;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom;" valign="bottom"> </td> <td colspan="2" style="vertical-align: top;" valign="bottom"> <div style="text-align: center; font-weight: bold;">2021<br/> </div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom;" valign="bottom"> </td> <td colspan="2" style="vertical-align: top;" valign="bottom"> <div style="text-align: center; font-weight: bold;">2020<br/> </div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom;" valign="bottom"> </td> <td colspan="2" style="vertical-align: top;" valign="bottom"> <div style="text-align: center; font-weight: bold;">2019<br/> </div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; white-space: nowrap;" valign="bottom"> </td> </tr> <tr> <td style="vertical-align: top; width: 64%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" rowspan="1" style="vertical-align: bottom; width: 1%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="2" rowspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold; text-align: center;">$’000</div> </td> <td colspan="1" rowspan="1" style="text-align: center; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" rowspan="1" style="vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); text-align: center;" valign="bottom"> </td> <td colspan="2" rowspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold; text-align: center;">$’000</div> </td> <td colspan="1" rowspan="1" style="text-align: center; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" rowspan="1" style="vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); text-align: center;" valign="bottom"> </td> <td colspan="2" rowspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold; text-align: center;">$’000</div> </td> <td colspan="1" rowspan="1" style="text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px; white-space: nowrap;" valign="bottom"> </td> </tr> <tr> <td style="vertical-align: top; width: 64%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt; font-style: normal; font-weight: bold;">Loss before tax</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="font-weight: bold;">9,202</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); font-weight: bold; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); font-weight: bold;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); font-weight: bold;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="font-weight: bold;">446</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); font-weight: bold; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); font-weight: bold;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); font-weight: bold;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="font-weight: bold;">310</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> </tr> <tr> <td style="vertical-align: top; width: 64%;" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Tax credit calculated at the domestic tax rate <span style="text-indent: 0pt;">12.5</span>%</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%;" valign="bottom"> <div>(1,150</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; white-space: nowrap;" valign="bottom"> <div>)</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%;" valign="bottom"> <div>(56</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; white-space: nowrap;" valign="bottom"> <div>)</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%;" valign="bottom"> <div>(39</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; white-space: nowrap;" valign="bottom"> <div>)</div> </td> </tr> <tr> <td style="vertical-align: top; width: 64%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Tax effects of:</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> </tr> <tr> <td style="vertical-align: top; width: 64%; padding-bottom: 2px;" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Losses for which no deferred tax asset was recognized</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div>1,150</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div>56</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div>39</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px; white-space: nowrap;" valign="bottom"> </td> </tr> <tr> <td style="vertical-align: top; width: 64%; background-color: rgb(204, 238, 255); padding-bottom: 4px;" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Tax charge/(credit)</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); padding-bottom: 4px;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255); border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> <div>—</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); border-bottom: 4px double rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255); border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> <div>—</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); border-bottom: 4px double rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255); border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> <div>—</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); padding-bottom: 4px; white-space: nowrap;" valign="bottom"> </td> </tr> </table>

-9202000

-446000

-310000

0.125

-1150000

-56000

-39000

1150000

56000

39000

<div style="font-family: 'Times New Roman'; font-size: 10pt;"><span style="font-weight: bold;">8. Deferred income taxes</span></div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">At December 31, 2021, the Group had unused net losses of $10 million (2020: $835 thousand). In order to utilize any of these unused losses, the Group would need to be regarded as carrying on a trade for Irish corporate tax purposes. Once regarded as carrying on a trade and subject to other conditions being met, such as, that the related expenses giving rise to the losses are tax deductible, the unused tax losses can be carried forward indefinitely against future trading income. On this basis, the Group has concluded that no deferred tax assets at December 31, 2021 or 2020 should be recognized. There is no certainty that we will generate sufficient taxable profits within the required timeframe to be able to utilize these tax loss carry-forwards in full.</div>

10000000

835000

<div style="font-family: 'Times New Roman'; font-size: 10pt;"><span style="font-weight: bold;">9. Other current assets</span></div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <table cellpadding="0" cellspacing="0" class="cfttable" style="font-family: 'Times New Roman'; font-size: 10pt; text-align: left; color: #000000; width: 100%;"> <tr> <td style="vertical-align: top; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="6" style="vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-weight: bold; white-space: nowrap;" valign="bottom"> <div style="text-align: center;">Year ended</div> <div style="text-align: center;">December 31,</div> </td> </tr> <tr> <td style="vertical-align: top;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom;" valign="bottom"> </td> <td colspan="2" style="vertical-align: top;" valign="bottom"> <div style="text-align: center; font-weight: bold;"> 2021<br/> </div> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold;" valign="bottom"> </td> <td colspan="2" style="vertical-align: top;" valign="bottom"> <div style="text-align: center; font-weight: bold;">2020<br/> </div> </td> </tr> <tr> <td style="vertical-align: top; width: 76.76%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="2" rowspan="1" style="vertical-align: bottom; width: 10.13%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold; text-align: center;">$’000</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="2" rowspan="1" style="vertical-align: bottom; width: 10.13%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold; text-align: center;">$’000</div> </td> </tr> <tr> <td style="vertical-align: top; width: 76.76%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Prepaid expenses</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>3,008</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>6</div> </td> </tr> <tr> <td style="vertical-align: top; width: 76.76%;" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">VAT receivable</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%;" valign="bottom"> <div>48</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%;" valign="bottom"> <div>6</div> </td> </tr> <tr> <td style="vertical-align: top; width: 76.76%; padding-bottom: 2px; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Other</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; padding-bottom: 2px; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> <div>10</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> <div>5</div> </td> </tr> <tr> <td style="vertical-align: top; width: 76.76%; padding-bottom: 4px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; padding-bottom: 4px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold;">3,066</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 4px double rgb(0, 0, 0); font-weight: bold; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 4px double rgb(0, 0, 0); font-weight: bold;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 4px double rgb(0, 0, 0); font-weight: bold;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold;">17</div> </td> </tr> </table>

<table cellpadding="0" cellspacing="0" class="cfttable" style="font-family: 'Times New Roman'; font-size: 10pt; text-align: left; color: #000000; width: 100%;"> <tr> <td style="vertical-align: top; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="6" style="vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-weight: bold; white-space: nowrap;" valign="bottom"> <div style="text-align: center;">Year ended</div> <div style="text-align: center;">December 31,</div> </td> </tr> <tr> <td style="vertical-align: top;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom;" valign="bottom"> </td> <td colspan="2" style="vertical-align: top;" valign="bottom"> <div style="text-align: center; font-weight: bold;"> 2021<br/> </div> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold;" valign="bottom"> </td> <td colspan="2" style="vertical-align: top;" valign="bottom"> <div style="text-align: center; font-weight: bold;">2020<br/> </div> </td> </tr> <tr> <td style="vertical-align: top; width: 76.76%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="2" rowspan="1" style="vertical-align: bottom; width: 10.13%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold; text-align: center;">$’000</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="2" rowspan="1" style="vertical-align: bottom; width: 10.13%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold; text-align: center;">$’000</div> </td> </tr> <tr> <td style="vertical-align: top; width: 76.76%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Prepaid expenses</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>3,008</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>6</div> </td> </tr> <tr> <td style="vertical-align: top; width: 76.76%;" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">VAT receivable</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%;" valign="bottom"> <div>48</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%;" valign="bottom"> <div>6</div> </td> </tr> <tr> <td style="vertical-align: top; width: 76.76%; padding-bottom: 2px; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Other</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; padding-bottom: 2px; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> <div>10</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> <div>5</div> </td> </tr> <tr> <td style="vertical-align: top; width: 76.76%; padding-bottom: 4px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; padding-bottom: 4px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold;">3,066</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 4px double rgb(0, 0, 0); font-weight: bold; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 4px double rgb(0, 0, 0); font-weight: bold;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 4px double rgb(0, 0, 0); font-weight: bold;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold;">17</div> </td> </tr> </table>

3008000

6000

48000

6000

10000

5000

3066000

17000

<div style="font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">10. Property, plant and equipment</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <table cellpadding="0" cellspacing="0" class="cfttable" style="font-family: 'Times New Roman'; font-size: 10pt; text-align: left; color: rgb(0, 0, 0); width: 100%;"> <tr> <td style="vertical-align: top; font-weight: bold; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="font-weight: bold; text-align: center; vertical-align: bottom; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="2" style="vertical-align: bottom; font-weight: bold; text-align: center; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div>Computer Equipment</div> <div>$’000</div> </td> <td colspan="1" style="font-weight: bold; text-align: left; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="font-weight: bold; text-align: center; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="2" style="vertical-align: bottom; font-weight: bold; text-align: center; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div>Office</div> <div>Equipment</div> <div>$’000</div> </td> <td colspan="1" style="font-weight: bold; text-align: left; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="font-weight: bold; text-align: center; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="2" style="vertical-align: bottom; font-weight: bold; text-align: center; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div>Medical</div> <div>Devices</div> <div>$’000</div> </td> <td colspan="1" style="font-weight: bold; text-align: left; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="font-weight: bold; text-align: center; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="2" style="vertical-align: bottom; font-weight: bold; text-align: center; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div>Total</div> <div>$’000</div> </td> <td colspan="1" style="font-weight: bold; text-align: left; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> </tr> <tr> <td style="vertical-align: top; width: 52%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt; font-style: italic; font-weight: bold;">Cost</div> </td> <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="2" rowspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"><br/> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="2" rowspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"><br/> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="2" rowspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"><br/> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="2" rowspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"><br/> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> </tr> <tr> <td style="vertical-align: top; width: 52%;" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">At January 1, <span style="text-indent: 0pt;">2021</span></div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%;" valign="bottom"> <div>—</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%;" valign="bottom"> <div>—</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%;" valign="bottom"> <div>—</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%;" valign="bottom"> <div>—</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; white-space: nowrap;" valign="bottom"> </td> </tr> <tr> <td style="vertical-align: top; width: 52%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Additions</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>57</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>8</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>39</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>104</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> </tr> <tr> <td style="vertical-align: top; width: 52%; padding-bottom: 2px;" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Exchange difference</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div>(2</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> <div>)</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div>—</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div>(1</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> <div>)</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div>(3</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> <div>)</div> </td> </tr> <tr> <td style="vertical-align: top; width: 52%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt; font-weight: bold;">At December 31, <span style="text-indent: 0pt;">2021</span></div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="font-weight: bold;">55</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="font-weight: bold;">8</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="font-weight: bold;">38</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="font-weight: bold;">101</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> </tr> <tr> <td style="vertical-align: top; width: 52%;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; white-space: nowrap;" valign="bottom"> </td> </tr> <tr> <td style="vertical-align: top; width: 52%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt; font-style: italic; font-weight: bold;">Accumulated Depreciation</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> </tr> <tr> <td style="vertical-align: top; width: 52%;" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">At January 1, <span style="text-indent: 0pt;">2021</span></div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%;" valign="bottom"> <div>—</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%;" valign="bottom"> <div>—</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%;" valign="bottom"> <div>—</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%;" valign="bottom"> <div>—</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; white-space: nowrap;" valign="bottom"> </td> </tr> <tr> <td style="vertical-align: top; width: 52%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Additions</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>10</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>1</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>9</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>20</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> </tr> <tr> <td style="vertical-align: top; width: 52%; padding-bottom: 2px;" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Exchange difference</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div>(1</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> <div>)</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div>—</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div>—</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div>(1</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px; white-space: nowrap;" valign="bottom"> <div>)</div> </td> </tr> <tr> <td style="vertical-align: top; width: 52%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt; font-weight: bold;">At December 31, <span style="text-indent: 0pt;">2021</span></div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="font-weight: bold;">9</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="font-weight: bold;">1</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="font-weight: bold;">9</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="font-weight: bold;">19</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> </tr> <tr> <td style="vertical-align: top; width: 52%;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; white-space: nowrap;" valign="bottom"> </td> </tr> <tr> <td style="vertical-align: top; width: 52%; padding-bottom: 2px; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt; font-weight: bold;">Net Book Amount</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> </tr> <tr> <td style="vertical-align: top; width: 52%; padding-bottom: 4px;" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt; font-weight: bold;">At December 31, <span style="text-indent: 0pt;">2021</span></div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; padding-bottom: 4px;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold;">46</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 4px double rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold;">7</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 4px double rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold;">29</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 4px double rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold;">82</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 4px; white-space: nowrap;" valign="bottom"> </td> </tr> </table> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> <br/> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">In 2021, the investments in property, plant & equipment relate to hardware due to the increased number of employees and the acquisition of medical devices relating to the Group’s technical development and clinical trials.<br/> <br/> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Depreciation expense of $15 thousand (2020: $<span style="-sec-ix-hidden:Fact_9a0dc7b00dce4aab9eff4dce7cb1d5e6">nil</span>, 2019: $<span style="-sec-ix-hidden:Fact_2c9db2d3347a4ce08610d118391eb0f2">nil</span>) has been charged in research and development expenses and $4 thousand (2020: $<span style="-sec-ix-hidden:Fact_df6be95c6de14be788ca94b42e405cee">nil</span>, 2019: $<span style="-sec-ix-hidden:Fact_fa71660588da48439961b6289e3d4b8a">nil</span>) in general and administration expenses.</div>

<table cellpadding="0" cellspacing="0" class="cfttable" style="font-family: 'Times New Roman'; font-size: 10pt; text-align: left; color: rgb(0, 0, 0); width: 100%;"> <tr> <td style="vertical-align: top; font-weight: bold; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="font-weight: bold; text-align: center; vertical-align: bottom; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="2" style="vertical-align: bottom; font-weight: bold; text-align: center; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div>Computer Equipment</div> <div>$’000</div> </td> <td colspan="1" style="font-weight: bold; text-align: left; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="font-weight: bold; text-align: center; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="2" style="vertical-align: bottom; font-weight: bold; text-align: center; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div>Office</div> <div>Equipment</div> <div>$’000</div> </td> <td colspan="1" style="font-weight: bold; text-align: left; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="font-weight: bold; text-align: center; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="2" style="vertical-align: bottom; font-weight: bold; text-align: center; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div>Medical</div> <div>Devices</div> <div>$’000</div> </td> <td colspan="1" style="font-weight: bold; text-align: left; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="font-weight: bold; text-align: center; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="2" style="vertical-align: bottom; font-weight: bold; text-align: center; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div>Total</div> <div>$’000</div> </td> <td colspan="1" style="font-weight: bold; text-align: left; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> </tr> <tr> <td style="vertical-align: top; width: 52%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt; font-style: italic; font-weight: bold;">Cost</div> </td> <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="2" rowspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"><br/> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="2" rowspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"><br/> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="2" rowspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"><br/> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="2" rowspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"><br/> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> </tr> <tr> <td style="vertical-align: top; width: 52%;" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">At January 1, <span style="text-indent: 0pt;">2021</span></div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%;" valign="bottom"> <div>—</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%;" valign="bottom"> <div>—</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%;" valign="bottom"> <div>—</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%;" valign="bottom"> <div>—</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; white-space: nowrap;" valign="bottom"> </td> </tr> <tr> <td style="vertical-align: top; width: 52%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Additions</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>57</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>8</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>39</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>104</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> </tr> <tr> <td style="vertical-align: top; width: 52%; padding-bottom: 2px;" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Exchange difference</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div>(2</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> <div>)</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div>—</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div>(1</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> <div>)</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div>(3</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> <div>)</div> </td> </tr> <tr> <td style="vertical-align: top; width: 52%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt; font-weight: bold;">At December 31, <span style="text-indent: 0pt;">2021</span></div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="font-weight: bold;">55</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="font-weight: bold;">8</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="font-weight: bold;">38</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="font-weight: bold;">101</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> </tr> <tr> <td style="vertical-align: top; width: 52%;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; white-space: nowrap;" valign="bottom"> </td> </tr> <tr> <td style="vertical-align: top; width: 52%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt; font-style: italic; font-weight: bold;">Accumulated Depreciation</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> </tr> <tr> <td style="vertical-align: top; width: 52%;" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">At January 1, <span style="text-indent: 0pt;">2021</span></div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%;" valign="bottom"> <div>—</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%;" valign="bottom"> <div>—</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%;" valign="bottom"> <div>—</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%;" valign="bottom"> <div>—</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; white-space: nowrap;" valign="bottom"> </td> </tr> <tr> <td style="vertical-align: top; width: 52%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Additions</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>10</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>1</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>9</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>20</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> </tr> <tr> <td style="vertical-align: top; width: 52%; padding-bottom: 2px;" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Exchange difference</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div>(1</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> <div>)</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div>—</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div>—</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div>(1</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px; white-space: nowrap;" valign="bottom"> <div>)</div> </td> </tr> <tr> <td style="vertical-align: top; width: 52%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt; font-weight: bold;">At December 31, <span style="text-indent: 0pt;">2021</span></div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="font-weight: bold;">9</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="font-weight: bold;">1</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="font-weight: bold;">9</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="font-weight: bold;">19</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> </tr> <tr> <td style="vertical-align: top; width: 52%;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; white-space: nowrap;" valign="bottom"> </td> </tr> <tr> <td style="vertical-align: top; width: 52%; padding-bottom: 2px; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt; font-weight: bold;">Net Book Amount</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> </tr> <tr> <td style="vertical-align: top; width: 52%; padding-bottom: 4px;" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt; font-weight: bold;">At December 31, <span style="text-indent: 0pt;">2021</span></div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; padding-bottom: 4px;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold;">46</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 4px double rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold;">7</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 4px double rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold;">29</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 4px double rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold;">82</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 4px; white-space: nowrap;" valign="bottom"> </td> </tr> </table>

57000

8000

39000

104000

-2000

-1000

-3000

55000

8000

38000

101000

10000

1000

9000

20000

-1000

-9000

-1000

-9000

-19000

46000

7000

29000

82000

15000

4000

<div style="font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">11. Trade payables</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Trade payables primarily represents amounts incurred for the provision of manufacturing, research and consulting services and legal and professional fees, which have been billed and are outstanding at the end of the year. Trade payables are due to be settled at different times within 12 months.</div>

<div style="font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">12. Other current liabilities</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <table cellpadding="0" cellspacing="0" class="cfttable" style="font-family: 'Times New Roman'; font-size: 10pt; text-align: left; color: #000000; width: 100%;"> <tr> <td style="vertical-align: top; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="6" style="vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-weight: bold; white-space: nowrap;" valign="bottom"> <div style="text-align: center;">Year ended</div> <div style="text-align: center;">December 31,</div> </td> </tr> <tr> <td style="vertical-align: top;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom;" valign="bottom"> </td> <td colspan="2" style="vertical-align: top;" valign="bottom"> <div style="text-align: center; font-weight: bold;"> 2021<br/> </div> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold;" valign="bottom"> </td> <td colspan="2" style="vertical-align: top;" valign="bottom"> <div style="text-align: center; font-weight: bold;">2020<br/> </div> </td> </tr> <tr> <td style="vertical-align: top; width: 76.76%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="2" rowspan="1" style="vertical-align: bottom; width: 10.13%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold; text-align: center;">$’000</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="2" rowspan="1" style="vertical-align: bottom; width: 10.13%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold; text-align: center;">$’000</div> </td> </tr> <tr> <td style="vertical-align: top; width: 76.76%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Accruals</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>1,698</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>242</div> </td> </tr> <tr> <td style="vertical-align: top; width: 76.76%;" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Social security payable</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%;" valign="bottom"> <div>96</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%;" valign="bottom"> <div>3</div> </td> </tr> <tr> <td style="vertical-align: top; width: 76.76%; padding-bottom: 2px; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Other</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; padding-bottom: 2px; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> <div>72</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> <div>—</div> </td> </tr> <tr> <td style="vertical-align: top; width: 76.76%; padding-bottom: 4px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; padding-bottom: 4px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold;">1,866</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 4px double rgb(0, 0, 0); font-weight: bold; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 4px double rgb(0, 0, 0); font-weight: bold;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 4px double rgb(0, 0, 0); font-weight: bold;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold;">245</div> </td> </tr> </table>

<table cellpadding="0" cellspacing="0" class="cfttable" style="font-family: 'Times New Roman'; font-size: 10pt; text-align: left; color: #000000; width: 100%;"> <tr> <td style="vertical-align: top; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="6" style="vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-weight: bold; white-space: nowrap;" valign="bottom"> <div style="text-align: center;">Year ended</div> <div style="text-align: center;">December 31,</div> </td> </tr> <tr> <td style="vertical-align: top;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom;" valign="bottom"> </td> <td colspan="2" style="vertical-align: top;" valign="bottom"> <div style="text-align: center; font-weight: bold;"> 2021<br/> </div> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold;" valign="bottom"> </td> <td colspan="2" style="vertical-align: top;" valign="bottom"> <div style="text-align: center; font-weight: bold;">2020<br/> </div> </td> </tr> <tr> <td style="vertical-align: top; width: 76.76%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="2" rowspan="1" style="vertical-align: bottom; width: 10.13%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold; text-align: center;">$’000</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; font-weight: bold; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="2" rowspan="1" style="vertical-align: bottom; width: 10.13%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold; text-align: center;">$’000</div> </td> </tr> <tr> <td style="vertical-align: top; width: 76.76%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Accruals</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>1,698</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>242</div> </td> </tr> <tr> <td style="vertical-align: top; width: 76.76%;" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Social security payable</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%;" valign="bottom"> <div>96</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%;" valign="bottom"> <div>3</div> </td> </tr> <tr> <td style="vertical-align: top; width: 76.76%; padding-bottom: 2px; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Other</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; padding-bottom: 2px; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> <div>72</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> <div>—</div> </td> </tr> <tr> <td style="vertical-align: top; width: 76.76%; padding-bottom: 4px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; padding-bottom: 4px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold;">1,866</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 4px double rgb(0, 0, 0); font-weight: bold; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 4px double rgb(0, 0, 0); font-weight: bold;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 4px double rgb(0, 0, 0); font-weight: bold;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold;">245</div> </td> </tr> </table>

1698000

242000

96000

3000

72000

1866000

245000

<div style="font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">13. Share capital and reserves</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">Share capital</div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;"> <br/> </div> <table cellpadding="0" cellspacing="0" class="cfttable" style="font-family: 'Times New Roman'; font-size: 10pt; text-align: left; color: rgb(0, 0, 0); width: 100%;"> <tr> <td style="vertical-align: top;" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt; font-style: italic;">Issued and fully paid shares:</div> </td> <td colspan="1" style="text-align: center; vertical-align: bottom;" valign="bottom"> </td> <td colspan="2" style="vertical-align: bottom; text-align: center;"> <div style="font-weight: bold;">Number of</div> <div style="font-weight: bold;"> outstanding</div> <div style="font-weight: bold;"> shares</div> </td> <td colspan="1" style="text-align: center; vertical-align: bottom; white-space: nowrap;"> </td> <td colspan="1" style="font-weight: bold; text-align: center; vertical-align: bottom;"> </td> <td colspan="2" style="vertical-align: bottom; font-weight: bold; text-align: center;"> <div>Share capital</div> </td> <td colspan="1" style="font-weight: bold; text-align: center; vertical-align: bottom; white-space: nowrap;"> </td> <td colspan="1" style="font-weight: bold; text-align: center; vertical-align: bottom;"> </td> <td colspan="2" style="vertical-align: bottom; font-weight: bold; text-align: center;"> <div>Additional</div> <div> paid-in</div> <div> capital</div> </td> </tr> <tr> <td rowspan="1" style="vertical-align: top; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" rowspan="1" style="text-align: center; vertical-align: bottom; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="2" rowspan="1" style="vertical-align: bottom; text-align: center; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" rowspan="1" style="text-align: left; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" rowspan="1" style="font-weight: bold; text-align: center; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" rowspan="1" style="font-weight: bold; text-align: left; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div> </div> </td> <td colspan="1" rowspan="1" style="font-weight: bold; vertical-align: bottom; text-align: right; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="text-align: center;">$’000</div> </td> <td colspan="1" rowspan="1" style="font-weight: bold; text-align: left; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> <div><br/> </div> </td> <td colspan="1" rowspan="1" style="font-weight: bold; text-align: center; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" rowspan="1" style="font-weight: bold; text-align: left; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div> </div> </td> <td colspan="1" rowspan="1" style="font-weight: bold; vertical-align: bottom; text-align: right; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="text-align: center;">$’000</div> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%; background-color: rgb(204, 238, 255); padding-bottom: 2px;" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt; font-weight: bold;">At January 1, <span style="text-indent: 0pt;">2019</span><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)</sup></div> </td> <td colspan="1" style="text-align: right; color: rgb(0, 0, 0); vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="color: rgb(0, 0, 0); text-align: left; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="color: rgb(0, 0, 0); vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold;">70,000,000</div> </td> <td colspan="1" style="color: rgb(0, 0, 0); text-align: left; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold;">801</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div>—</div> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%;" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt; font-weight: bold;">At December 31, <span style="text-indent: 0pt;">2019</span> <sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(2)</sup></div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%;" valign="bottom"> <div style="font-weight: bold;">70,000,000</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%;" valign="bottom"> <div style="font-weight: bold;">801</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%;" valign="bottom"> <div>—</div> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%; padding-bottom: 2px; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Issuance of share capital - Series A preferred shares (i)<br/> </div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%; padding-bottom: 2px; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> <div>5,923,079</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> <div>70</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> <div>5,430</div> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%;" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt; font-weight: bold;">At December 31, <span style="text-indent: 0pt;">2020</span> <sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(2)</sup></div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%;" valign="bottom"> <div style="font-weight: bold;">75,923,079</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%;" valign="bottom"> <div style="font-weight: bold;">871</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%;" valign="bottom"> <div style="font-weight: bold;">5,430</div> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Issuance of share capital - A Ordinary Shares (ii)<br/> </div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>25,000</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>—</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>—</div> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%;" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Issuance of share capital - Series B preferred shares (iii)<br/> </div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%;" valign="bottom"> <div>25,379,047</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%;" valign="bottom"> <div>302</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%;" valign="bottom"> <div>118,518</div> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Share exchange (iv)<br/> </div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>—</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>(160</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> <div>)</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>160</div> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%;" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Redemption of A Ordinary Shares (v)<br/> </div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%;" valign="bottom"> <div>(25,000</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; white-space: nowrap;" valign="bottom"> <div>)</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%;" valign="bottom"> <div>—</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%;" valign="bottom"> <div>—</div> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Share consolidation (vi)<br/> </div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>(60,781,276</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> <div>)</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>—</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>—</div> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%; padding-bottom: 2px;" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Issue of share capital (vii)<br/> </div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div>11,499,999</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div>288</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div>167,340</div> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%; padding-bottom: 4px; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt; font-weight: bold;">At December 31, <span style="text-indent: 0pt;">2021</span></div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%; padding-bottom: 4px; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; border-bottom: 4px double rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 4px double rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> <div style="font-weight: bold;">52,020,849</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; border-bottom: 4px double rgb(0, 0, 0); background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%; border-bottom: 4px double rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; border-bottom: 4px double rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 4px double rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> <div style="font-weight: bold;">1,301</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; border-bottom: 4px double rgb(0, 0, 0); background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%; border-bottom: 4px double rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; border-bottom: 4px double rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 4px double rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> <div style="font-weight: bold;">291,448</div> </td> </tr> </table> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> <br/> </div> <table cellpadding="0" cellspacing="0" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;"> <tr> <td style="width: 18pt; vertical-align: top; font-weight: normal;"><sup>(1)</sup><br/> </td> <td style="width: auto; vertical-align: top; text-align: justify;"> <div>In 2018, the GH Research Ireland Limited issued 70,000,000 ordinary shares with a nominal value of €0.01 for which a receivable was recognized and the related cash flow occurred in 2019.</div> </td> </tr> </table> <table cellpadding="0" cellspacing="0" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;"> <tr> <td style="width: 18pt; vertical-align: top; font-weight: bold;"><span style="font-weight: normal;"><sup>(2)</sup></span><br/> </td> <td style="width: auto; vertical-align: top; text-align: justify;"> <div>Share information presented as of December 31, 2019 and 2020, and for the financial year then ended, is prior to the incorporation of GH Research PLC and relates solely to GH Ireland Research Limited and does not give effect to the 2.50-for-one share consolidation described below.</div> </td> </tr> </table> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> <br/> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The authorized share capital of GH Research PLC is 40,000,000,000 ordinary shares of nominal value $0.025 each as of December 31, 2021.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <table cellpadding="0" cellspacing="0" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;"> <tr> <td style="width: 36pt; vertical-align: top;">(i)</td> <td style="width: auto; vertical-align: top; text-align: justify;"> <div>Share issuance – Series A preferred shares</div> </td> </tr> </table> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">On November 2, 2020, GH Research Ireland Limited increased its share capital through the issuance of 5,384,617 Series A preferred shares with a nominal value of €0.01 (which were redesignated into 2,153,847 ordinary <span style="color: rgb(0, 0, 0);">shares of GH Research PLC prior to the closing of the initial public offering</span>). The proceeds of this issuance were $5 million. On December 22, 2020, a further increase of share capital was completed through the issuance of 538,462 Series A preferred shares (which were redesignated into 215,385 ordinary <span style="color: rgb(0, 0, 0);">shares of GH Research PLC prior to the closing of the initial public offering</span>) resulting in proceeds of $500 thousand.</div> <div style="text-align: justify; margin-left: 36pt; font-family: 'Times New Roman'; font-size: 10pt;"> <br/> </div> <table cellpadding="0" cellspacing="0" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;"> <tr> <td style="width: 36pt; vertical-align: top;">(ii)</td> <td style="width: auto; vertical-align: top; text-align: justify;"> <div>Incorporation of GH Research PLC</div> </td> </tr> </table> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">On March 29, 2021, GH Research PLC was incorporated with an authorized share capital of €25,000, divided into 25,000 A ordinary shares of nominal value €1.00 each. The sole subscriber to the incorporation constitution of GH Research PLC was Florian Schönharting who subscribed for 25,000 A ordinary shares of €1.00 each. The issuance and subsequent redemption is shown net within the issue of share capital.</div> <div style="text-align: justify; margin-left: 36pt; font-family: 'Times New Roman'; font-size: 10pt;"> <br/> </div> <table cellpadding="0" cellspacing="0" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;"> <tr> <td style="width: 36pt; vertical-align: top;">(iii)</td> <td style="width: auto; vertical-align: top; text-align: justify;"> <div>Share issuance – Series B preferred shares</div> </td> </tr> </table> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">On April 8, 2021, GH Research Ireland Limited issued 25,379,047 Series B preferred shares (which were redesignated into 10,151,618 ordinary <span style="color: rgb(0, 0, 0);">shares of GH Research PLC prior to the closing of the initial public offering</span>). The net proceeds of this issuance were $118.8 million, after deducting directly attributable transaction costs of $6.4 million.</div> <div style="text-align: justify; margin-left: 36pt; font-family: 'Times New Roman'; font-size: 10pt;"> <br/> </div> <table cellpadding="0" cellspacing="0" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;"> <tr> <td style="width: 36pt; vertical-align: top;">(iv)</td> <td style="width: auto; vertical-align: top; text-align: justify;"> <div>Share exchange</div> </td> </tr> </table> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">On May<span style="font-weight: bold;"> </span>27, 2021, as part of the corporate reorganization, all shareholders of GH Research Ireland Limited exchanged each of the shares held by them in GH Research Ireland Limited, which had a nominal value of €0.01, for shares of GH Research PLC of the same share classes with the same shareholders rights as the shares held by them in GH Research Ireland Limited, and as a result, GH Research Ireland Limited became a wholly-owned subsidiary of GH Research PLC.</div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">GH Research PLC issued the following shares:</div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;"> <br/> </div> <table cellpadding="0" cellspacing="0" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;"> <tr> <td style="width: 18pt; vertical-align: top; font-weight: bold;">-</td> <td style="width: auto; vertical-align: top; text-align: justify;"> <div>70,000,000 ordinary shares, nominal value $0.01 each;</div> </td> </tr> </table> <table cellpadding="0" cellspacing="0" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;"> <tr> <td style="width: 18pt; vertical-align: top; font-weight: bold;">-</td> <td style="width: auto; vertical-align: top; text-align: justify;"> <div>5,923,079 Series A preferred shares, nominal value $0.01 each; and</div> </td> </tr> </table> <table cellpadding="0" cellspacing="0" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;"> <tr> <td style="width: 18pt; vertical-align: top; font-weight: bold;">-</td> <td style="width: auto; vertical-align: top; text-align: justify;"> <div>25,379,047 Series B preferred shares, nominal value $0.01 each.</div> </td> </tr> </table> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> <br/> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">This resulted in a reduction in share capital and a corresponding increase in additional paid-in capital of $160 thousand.</div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;"> <br/> </div> <table cellpadding="0" cellspacing="0" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;"> <tr> <td style="width: 36pt; vertical-align: top;">(v)</td> <td style="width: auto; vertical-align: top; text-align: justify;"> <div>Redemption of A Ordinary Shares</div> </td> </tr> </table> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">On June 24, 2021, GH Research PLC redeemed 25,000 A ordinary shares of €1.00 each at par and, following the redemption, cancelled the 25,000 A ordinary shares of €1.00 each. The redemption amount of €25,000 is included in “Other current liabilities” at December 31, 2021. The issuance and redemption is shown net within the issue of share capital.</div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;"> <br/> </div> <table cellpadding="0" cellspacing="0" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;"> <tr> <td style="width: 36pt; vertical-align: top;">(vi)</td> <td style="width: auto; vertical-align: top; text-align: justify;"> <div>Conversion and share consolidation</div> </td> </tr> </table> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">On June 24, 2021, GH Research PLC (a) converted (i) 5,923,079 Series A preferred shares of nominal value $0.01 each into 5,923,079 ordinary shares of nominal value $0.01 each and (ii) 25,379,047 Series B preferred shares of nominal value $0.01 each into 25,379,047 ordinary shares of nominal value $0.01 each and (b) completed the 2.50-for-one share consolidation of the existing ordinary shares into an aggregate of 40,520,850 ordinary shares of nominal value $0.025 each.</div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;"> <br/> </div> <table cellpadding="0" cellspacing="0" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;"> <tr> <td style="width: 36pt; vertical-align: top;">(vii)</td> <td style="width: auto; vertical-align: top; text-align: justify;"> <div>Share issuance – IPO</div> </td> </tr> </table> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">On June 29, 2021, GH Research PLC closed its IPO of 11,499,999 ordinary shares on the Nasdaq Global Market at $16.00 per share. The net proceeds of the IPO were $167.6 million, after deducting underwriting discounts and directly attributable transaction costs of $16.4 million.</div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;"> <br/> </div> <div style="text-align: justify; font-style: italic; font-family: 'Times New Roman'; font-size: 10pt;">Dividend</div> <div style="text-align: justify; font-style: italic; font-family: 'Times New Roman'; font-size: 10pt;"> <br/> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">No dividends were declared or paid during the year (2020: $<span style="-sec-ix-hidden:Fact_8ca8f6f2819d4a8297495191d8b665ae">nil</span>; 2019: $<span style="-sec-ix-hidden:Fact_86bfc50dad67438c807e9814703d2354">nil</span>).</div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;"> <br/> </div> <div style="text-align: justify; font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">Reserves</div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;"> <br/> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Other reserve of $366 thousand as of December 31, 2021 (2020: $<span style="-sec-ix-hidden:Fact_0ce9fc35ac90447ba76cd78bc61ab27e">nil</span>) comprises amounts expensed in the Consolidated statement of comprehensive income in connection with awards made under the Share Option Plan (see note 15, “Share-based compensation”).</div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;"> <br/> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Foreign currency translation reserve of $5.9 million as of December 31, 2021 (2020: $200 thousand) consists of the cumulative currency translation adjustment in respect of GH Research Ireland Limited whose functional currency is euro. The translation adjustments arise from the retranslation of the profits of such operations from the average exchange rate for the year to the exchange rate at the statement of financial position date as well as the retranslation of the subsidiary’s applicable assets and liabilities.</div>

<div style="text-align: justify; font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">Share capital</div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;"> <br/> </div> <table cellpadding="0" cellspacing="0" class="cfttable" style="font-family: 'Times New Roman'; font-size: 10pt; text-align: left; color: rgb(0, 0, 0); width: 100%;"> <tr> <td style="vertical-align: top;" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt; font-style: italic;">Issued and fully paid shares:</div> </td> <td colspan="1" style="text-align: center; vertical-align: bottom;" valign="bottom"> </td> <td colspan="2" style="vertical-align: bottom; text-align: center;"> <div style="font-weight: bold;">Number of</div> <div style="font-weight: bold;"> outstanding</div> <div style="font-weight: bold;"> shares</div> </td> <td colspan="1" style="text-align: center; vertical-align: bottom; white-space: nowrap;"> </td> <td colspan="1" style="font-weight: bold; text-align: center; vertical-align: bottom;"> </td> <td colspan="2" style="vertical-align: bottom; font-weight: bold; text-align: center;"> <div>Share capital</div> </td> <td colspan="1" style="font-weight: bold; text-align: center; vertical-align: bottom; white-space: nowrap;"> </td> <td colspan="1" style="font-weight: bold; text-align: center; vertical-align: bottom;"> </td> <td colspan="2" style="vertical-align: bottom; font-weight: bold; text-align: center;"> <div>Additional</div> <div> paid-in</div> <div> capital</div> </td> </tr> <tr> <td rowspan="1" style="vertical-align: top; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" rowspan="1" style="text-align: center; vertical-align: bottom; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="2" rowspan="1" style="vertical-align: bottom; text-align: center; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" rowspan="1" style="text-align: left; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" rowspan="1" style="font-weight: bold; text-align: center; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" rowspan="1" style="font-weight: bold; text-align: left; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div> </div> </td> <td colspan="1" rowspan="1" style="font-weight: bold; vertical-align: bottom; text-align: right; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="text-align: center;">$’000</div> </td> <td colspan="1" rowspan="1" style="font-weight: bold; text-align: left; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> <div><br/> </div> </td> <td colspan="1" rowspan="1" style="font-weight: bold; text-align: center; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" rowspan="1" style="font-weight: bold; text-align: left; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div> </div> </td> <td colspan="1" rowspan="1" style="font-weight: bold; vertical-align: bottom; text-align: right; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="text-align: center;">$’000</div> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%; background-color: rgb(204, 238, 255); padding-bottom: 2px;" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt; font-weight: bold;">At January 1, <span style="text-indent: 0pt;">2019</span><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)</sup></div> </td> <td colspan="1" style="text-align: right; color: rgb(0, 0, 0); vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="color: rgb(0, 0, 0); text-align: left; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="color: rgb(0, 0, 0); vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold;">70,000,000</div> </td> <td colspan="1" style="color: rgb(0, 0, 0); text-align: left; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold;">801</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div>—</div> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%;" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt; font-weight: bold;">At December 31, <span style="text-indent: 0pt;">2019</span> <sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(2)</sup></div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%;" valign="bottom"> <div style="font-weight: bold;">70,000,000</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%;" valign="bottom"> <div style="font-weight: bold;">801</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%;" valign="bottom"> <div>—</div> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%; padding-bottom: 2px; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Issuance of share capital - Series A preferred shares (i)<br/> </div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%; padding-bottom: 2px; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> <div>5,923,079</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> <div>70</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> <div>5,430</div> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%;" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt; font-weight: bold;">At December 31, <span style="text-indent: 0pt;">2020</span> <sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(2)</sup></div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%;" valign="bottom"> <div style="font-weight: bold;">75,923,079</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%;" valign="bottom"> <div style="font-weight: bold;">871</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%;" valign="bottom"> <div style="font-weight: bold;">5,430</div> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Issuance of share capital - A Ordinary Shares (ii)<br/> </div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>25,000</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>—</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>—</div> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%;" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Issuance of share capital - Series B preferred shares (iii)<br/> </div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%;" valign="bottom"> <div>25,379,047</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%;" valign="bottom"> <div>302</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%;" valign="bottom"> <div>118,518</div> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Share exchange (iv)<br/> </div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>—</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>(160</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> <div>)</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>160</div> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%;" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Redemption of A Ordinary Shares (v)<br/> </div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%;" valign="bottom"> <div>(25,000</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; white-space: nowrap;" valign="bottom"> <div>)</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%;" valign="bottom"> <div>—</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%;" valign="bottom"> <div>—</div> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Share consolidation (vi)<br/> </div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>(60,781,276</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> <div>)</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>—</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>—</div> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%; padding-bottom: 2px;" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Issue of share capital (vii)<br/> </div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div>11,499,999</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div>288</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div>167,340</div> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%; padding-bottom: 4px; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt; font-weight: bold;">At December 31, <span style="text-indent: 0pt;">2021</span></div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%; padding-bottom: 4px; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; border-bottom: 4px double rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 4px double rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> <div style="font-weight: bold;">52,020,849</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; border-bottom: 4px double rgb(0, 0, 0); background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%; border-bottom: 4px double rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; border-bottom: 4px double rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 4px double rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> <div style="font-weight: bold;">1,301</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; border-bottom: 4px double rgb(0, 0, 0); background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%; border-bottom: 4px double rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 0.99%; border-bottom: 4px double rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 4px double rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> <div style="font-weight: bold;">291,448</div> </td> </tr> </table> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> <br/> </div> <table cellpadding="0" cellspacing="0" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;"> <tr> <td style="width: 18pt; vertical-align: top; font-weight: normal;"><sup>(1)</sup><br/> </td> <td style="width: auto; vertical-align: top; text-align: justify;"> <div>In 2018, the GH Research Ireland Limited issued 70,000,000 ordinary shares with a nominal value of €0.01 for which a receivable was recognized and the related cash flow occurred in 2019.</div> </td> </tr> </table> <table cellpadding="0" cellspacing="0" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;"> <tr> <td style="width: 18pt; vertical-align: top; font-weight: bold;"><span style="font-weight: normal;"><sup>(2)</sup></span><br/> </td> <td style="width: auto; vertical-align: top; text-align: justify;"> <div>Share information presented as of December 31, 2019 and 2020, and for the financial year then ended, is prior to the incorporation of GH Research PLC and relates solely to GH Ireland Research Limited and does not give effect to the 2.50-for-one share consolidation described below.</div> </td> </tr> </table>

70000000

801000

70000000

801000

5923079

70000

5430000

75923079

871000

5430000

25000

25379047

302000

118518000

160000

-160000

25000

-60781276 0 0

11499999

288000

167340000

52020849

1301000

291448000

70000000

0.01

2.50

40000000000

0.025

5384617

0.01

2153847

5000000

538462

215385

500000

25000

1.00

25000

1.00

25379047

10151618

118800000

6400000

0.01

70000000

0.01

5923079

0.01

25379047

0.01

160000

25000

1.00

25000

1.00

25000 -5923079 0.01 5923079 0.01 -25379047 0.01 25379047 0.01 2.50 40520850 0.025

11499999

16.00

167600000

16400000

366000

-5900000

200000

<div style="font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">14. Contingencies</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The Group has no contingencies at the balance sheet date.</div>

<div style="font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">15. Share based compensation</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-style: italic; font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">Share Options</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">In June 2021, the Company adopted a share option plan referred to herein as the Share Option Plan under which grants of options are made to eligible participants. The Company has reserved 1,202,734 ordinary shares for future issuance under the Share Option Plan, which include ordinary shares pursuant to share-based equity awards issued to date. As of December 31, 2021, the Company has 1,045,547 ordinary shares available for the future issuance of share-based equity awards.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Under the Share Option Plan, any director (including our directors and directors of any other member of our group who are not active employees of the Company or any other company that is a member of our group) or employee of a member of the group or key consultant is eligible to be nominated by our remuneration committee to receive options.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The exercise price per share option is generally set by the Company at the closing market price on the day prior to grant. The awards generally vest 25% on the first anniversary of the date of grant, and thereafter evenly on a monthly basis over the subsequent three years in addition to a 2 year service condition. The contractual term (expiration) of each share option award granted is eight years from the date of grant.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Under the grant, the options may be settled only in ordinary shares of the Company. Therefore, the grants of share options under the Share Option Plan have been accounted for as equity-settled under IFRS 2. As such, the Company records a charge for the vested portion of award grants and for partially earned but non-vested portions of award grants. This results in a front-loaded charge to the Company’s consolidated statement of comprehensive income and a corresponding increase to Other Reserves within equity on the consolidated statement of financial position.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">During the year ended December 31, 2021, the Company granted the option to purchase 149,891 ordinary shares, respectively, to employees which were in line with the general terms of the Share Option Plan as described above.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">On September 24, 2021, the Company granted the option to purchase 7,296 ordinary shares to members of the board of directors which vested on the date of grant subject to a 2 year service condition, with an exercise price of $2.05.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The following table summarizes the share option awards outstanding as of December 31, 2021:</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <table border="0" cellpadding="0" cellspacing="0" class="cfttable" style="font-family: 'Times New Roman'; font-size: 10pt; text-align: left; color: #000000; width: 100%;"> <tr> <td style="vertical-align: top; padding-bottom: 2px; font-weight: bold; width: 65%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; padding-bottom: 2px; font-weight: bold; width: 1%;" valign="bottom"> </td> <td colspan="2" style="vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); font-weight: bold; text-align: center; white-space: nowrap;"> <div>Average exercise</div> <div>price per share</div> <div>in</div> <div>USD</div> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold; text-align: center; border-bottom: 2px solid rgb(0, 0, 0); width: 1%; white-space: nowrap;"> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold; text-align: center; border-bottom: 2px solid rgb(0, 0, 0); width: 1%;"> </td> <td colspan="2" style="vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); text-align: center;"> <div style="font-weight: bold;">Number of</div> <div style="font-weight: bold;">awards</div> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold; text-align: center; border-bottom: 2px solid rgb(0, 0, 0); width: 1%; white-space: nowrap;"> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold; text-align: center; border-bottom: 2px solid rgb(0, 0, 0); width: 1%;"> </td> <td colspan="2" style="vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); font-weight: bold; text-align: center;"> <div>Weighted average</div> <div>remaining</div> <div>life</div> <div>in years</div> </td> </tr> <tr> <td style="vertical-align: top; width: 65%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="font-weight: bold;">At December 31, 2020</div> </td> <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.47%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>—</div> </td> <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.03%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>—</div> </td> <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.03%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>—</div> </td> </tr> <tr> <td style="vertical-align: top; width: 65%; padding-bottom: 2px;" valign="bottom"> <div>Granted</div> </td> <td colspan="1" style="vertical-align: bottom; width: 1%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 1%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.47%; padding-bottom: 2px;" valign="bottom"> <div>15.80</div> </td> <td colspan="1" style="vertical-align: bottom; width: 1%; padding-bottom: 2px; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 1%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.03%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div>157,187</div> </td> <td colspan="1" style="vertical-align: bottom; width: 1%; padding-bottom: 2px; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 1%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 1%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.03%; padding-bottom: 2px;" valign="bottom"> <div>7.62</div> </td> </tr> <tr> <td style="vertical-align: top; width: 65%; padding-bottom: 2px; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="font-weight: bold;">At December 31, 2021</div> </td> <td colspan="1" style="vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.47%; padding-bottom: 2px; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="font-weight: bold;">15.80</div> </td> <td colspan="1" style="vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: rgb(204, 238, 255); font-weight: bold; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: rgb(204, 238, 255); font-weight: bold;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255); font-weight: bold;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.03%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> <div style="font-weight: bold;">157,187</div> </td> <td colspan="1" style="vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: rgb(204, 238, 255); font-weight: bold; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: rgb(204, 238, 255); font-weight: bold;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: rgb(204, 238, 255); font-weight: bold;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.03%; padding-bottom: 2px; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="font-weight: bold;">7.62</div> </td> </tr> </table> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> <br/> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">None of the awards outstanding as of December 31, 2021 were exercisable and they expire through 2029. As of December 31, 2021, 7,296 awards are vested and generally subject to a 2 year service condition.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The weighted average grant date fair value of awards granted during the year ended December 31, 2021 was $14.44 per award.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The fair values of the options granted were determined on the date of the grant using the Black-Scholes option-pricing model. The Company used an independent valuation firm to assist in calculating the fair value of the award grants per participant.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The fair values of the options granted during the year ended December 31, 2021 were determined on the date of the grant using the following assumptions:</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <table cellpadding="0" cellspacing="0" class="cfttable" style="font-family: 'Times New Roman'; font-size: 10pt; text-align: left; color: #000000; width: 100%;"> <tr> <td style="vertical-align: top; padding-bottom: 2px; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; padding-bottom: 2px; white-space: nowrap;" valign="bottom"> </td> <td colspan="2" style="vertical-align: top; border-bottom: #000000 solid 2px; white-space: nowrap;" valign="bottom"> <div style="text-align: center; font-weight: bold;">Year ended</div> <div style="text-align: center; font-weight: bold;">December 31, 2021</div> </td> </tr> <tr> <td style="vertical-align: top; width: 86.89%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Share price, in USD</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1.32%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 10.79%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-align: center;">15.00 - 23.74</div> </td> </tr> <tr> <td style="vertical-align: top; width: 86.89%;" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Strike price, in USD – employees (weighted average)</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1.32%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 10.79%;" valign="bottom"> <div style="text-align: center;">18.45</div> </td> </tr> <tr> <td style="vertical-align: top; width: 86.89%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Strike price, in USD – non-executive directors</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1.32%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 10.79%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-align: center;">2.05</div> </td> </tr> <tr> <td style="vertical-align: top; width: 86.89%;" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Expected volatility</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1.32%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 10.79%;" valign="bottom"> <div style="text-align: center;">90% - 95%</div> </td> </tr> <tr> <td style="vertical-align: top; width: 86.89%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Award life (weighted average)</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1.32%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 10.79%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-align: center;">5.95</div> </td> </tr> <tr> <td style="vertical-align: top; width: 86.89%;" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Expected dividends</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1.32%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 10.79%;" valign="bottom"> <div style="text-align: center;">—</div> </td> </tr> <tr> <td style="vertical-align: top; width: 86.89%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Risk-free interest rate</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1.32%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 10.79%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-align: center;">0.97% - 1.25%</div> </td> </tr> </table> <div style="font-family: 'Times New Roman'; font-size: 10pt;"><br/> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The expected volatility was based on selected volatility determined by median values observed among other comparable public companies.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The award life is based on the time interval between the date of grant and the date during the eight-year life after which, when making the grant, the Company expected on average that participants would exercise their options.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">As of December 31, 2021, the amount recorded as an increase to Other Reserves within equity on the consolidated statement of financial position of the Share Option Plan was $366 thousand. The amount of expense for all awards recognized for services received during the year ended December 31, 2021, was $366 thousand (2020: $<span style="-sec-ix-hidden:Fact_02756952ef7f4e7f94575cc375f0bcde">nil</span>, 2019: $<span style="-sec-ix-hidden:Fact_41260e6d6d99435a807bb9d1ee5bcf0b">nil</span>).</div>

1202734

1045547 0.25 P3Y P2Y P8Y

149891

7296

P2Y

2.05

<div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The following table summarizes the share option awards outstanding as of December 31, 2021:</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <table border="0" cellpadding="0" cellspacing="0" class="cfttable" style="font-family: 'Times New Roman'; font-size: 10pt; text-align: left; color: #000000; width: 100%;"> <tr> <td style="vertical-align: top; padding-bottom: 2px; font-weight: bold; width: 65%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; padding-bottom: 2px; font-weight: bold; width: 1%;" valign="bottom"> </td> <td colspan="2" style="vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); font-weight: bold; text-align: center; white-space: nowrap;"> <div>Average exercise</div> <div>price per share</div> <div>in</div> <div>USD</div> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold; text-align: center; border-bottom: 2px solid rgb(0, 0, 0); width: 1%; white-space: nowrap;"> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold; text-align: center; border-bottom: 2px solid rgb(0, 0, 0); width: 1%;"> </td> <td colspan="2" style="vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); text-align: center;"> <div style="font-weight: bold;">Number of</div> <div style="font-weight: bold;">awards</div> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold; text-align: center; border-bottom: 2px solid rgb(0, 0, 0); width: 1%; white-space: nowrap;"> </td> <td colspan="1" style="vertical-align: bottom; font-weight: bold; text-align: center; border-bottom: 2px solid rgb(0, 0, 0); width: 1%;"> </td> <td colspan="2" style="vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); font-weight: bold; text-align: center;"> <div>Weighted average</div> <div>remaining</div> <div>life</div> <div>in years</div> </td> </tr> <tr> <td style="vertical-align: top; width: 65%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="font-weight: bold;">At December 31, 2020</div> </td> <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.47%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>—</div> </td> <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.03%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>—</div> </td> <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.03%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>—</div> </td> </tr> <tr> <td style="vertical-align: top; width: 65%; padding-bottom: 2px;" valign="bottom"> <div>Granted</div> </td> <td colspan="1" style="vertical-align: bottom; width: 1%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 1%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.47%; padding-bottom: 2px;" valign="bottom"> <div>15.80</div> </td> <td colspan="1" style="vertical-align: bottom; width: 1%; padding-bottom: 2px; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 1%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.03%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div>157,187</div> </td> <td colspan="1" style="vertical-align: bottom; width: 1%; padding-bottom: 2px; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 1%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 1%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.03%; padding-bottom: 2px;" valign="bottom"> <div>7.62</div> </td> </tr> <tr> <td style="vertical-align: top; width: 65%; padding-bottom: 2px; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="font-weight: bold;">At December 31, 2021</div> </td> <td colspan="1" style="vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.47%; padding-bottom: 2px; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="font-weight: bold;">15.80</div> </td> <td colspan="1" style="vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: rgb(204, 238, 255); font-weight: bold; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: rgb(204, 238, 255); font-weight: bold;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255); font-weight: bold;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.03%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom"> <div style="font-weight: bold;">157,187</div> </td> <td colspan="1" style="vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: rgb(204, 238, 255); font-weight: bold; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: rgb(204, 238, 255); font-weight: bold;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: rgb(204, 238, 255); font-weight: bold;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.03%; padding-bottom: 2px; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="font-weight: bold;">7.62</div> </td> </tr> </table>

15.80

157187

P7Y7M13D

15.80

157187

P7Y7M13D

7296 P2Y 14.44

<div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The fair values of the options granted during the year ended December 31, 2021 were determined on the date of the grant using the following assumptions:</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <table cellpadding="0" cellspacing="0" class="cfttable" style="font-family: 'Times New Roman'; font-size: 10pt; text-align: left; color: #000000; width: 100%;"> <tr> <td style="vertical-align: top; padding-bottom: 2px; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; padding-bottom: 2px; white-space: nowrap;" valign="bottom"> </td> <td colspan="2" style="vertical-align: top; border-bottom: #000000 solid 2px; white-space: nowrap;" valign="bottom"> <div style="text-align: center; font-weight: bold;">Year ended</div> <div style="text-align: center; font-weight: bold;">December 31, 2021</div> </td> </tr> <tr> <td style="vertical-align: top; width: 86.89%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Share price, in USD</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1.32%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 10.79%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-align: center;">15.00 - 23.74</div> </td> </tr> <tr> <td style="vertical-align: top; width: 86.89%;" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Strike price, in USD – employees (weighted average)</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1.32%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 10.79%;" valign="bottom"> <div style="text-align: center;">18.45</div> </td> </tr> <tr> <td style="vertical-align: top; width: 86.89%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Strike price, in USD – non-executive directors</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1.32%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 10.79%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-align: center;">2.05</div> </td> </tr> <tr> <td style="vertical-align: top; width: 86.89%;" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Expected volatility</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1.32%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 10.79%;" valign="bottom"> <div style="text-align: center;">90% - 95%</div> </td> </tr> <tr> <td style="vertical-align: top; width: 86.89%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Award life (weighted average)</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1.32%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 10.79%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-align: center;">5.95</div> </td> </tr> <tr> <td style="vertical-align: top; width: 86.89%;" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Expected dividends</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1.32%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 10.79%;" valign="bottom"> <div style="text-align: center;">—</div> </td> </tr> <tr> <td style="vertical-align: top; width: 86.89%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Risk-free interest rate</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1.32%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 10.79%; background-color: rgb(204, 238, 255);" valign="bottom"> <div style="text-align: center;">0.97% - 1.25%</div> </td> </tr> </table>

15.00

23.74

18.45

2.05

0.90

0.95

5.95

0.0097

0.0125

P8Y

366000

<div style="font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">16. Related party disclosures</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Parties are considered to be related if one party has the ability, directly or indirectly, to control the other party or exercise significant influence over the other party in making financial and operating decisions.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">On April 8, 2021, GH Research Ireland Limited issued 5,270,400 Series B preferred shares (which were redesignated as into 2,108,159 ordinary shares prior to the closing of the IPO) to directors and entities affiliated with directors.</div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;"> <br/> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">On June 4, 2021, GH Research PLC granted the option to purchase 126,218 ordinary shares (which were redesignated into 50,487 ordinary shares prior to the closing of the IPO) to key management.</div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;"> <br/> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">On June 24, 2021, GH Research PLC redeemed 25,000 A ordinary shares of €1.00 each at par and, following the redemption, cancelled the 25,000 A ordinary shares of €1.00 each, see note 13, “Share capital and reserves” for details.</div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;"> <br/> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">On June 29, 2021, GH Research PLC issued 625,000 ordinary shares from the initial public offering to entities affiliated with directors.</div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;"> <br/> </div> <div style="font-style: italic; font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">Key Management Compensation</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"><br/> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Key management are those persons who have the authority and responsibility for planning, directing and controlling the activities of the Group. <span style="font-family: 'Times New Roman'; font-size: 10pt; color: #000000;">Key management is comprised of executive officers and the board of directors who served during the reporting period.</span></div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"><br/> </div> <table cellpadding="0" cellspacing="0" class="cfttable" style="font-family: 'Times New Roman'; font-size: 10pt; text-align: left; color: #000000; width: 100%;"> <tr> <td style="vertical-align: top; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="10" style="vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="text-align: center; font-weight: bold;">Year ended</div> <div style="text-align: center; font-weight: bold;">December 31,</div> </td> </tr> <tr> <td style="vertical-align: top;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom;" valign="bottom"> </td> <td colspan="2" style="vertical-align: top;" valign="bottom"> <div style="text-align: center;"> <span style="font-weight: bold;">2021</span><br/> </div> </td> <td colspan="1" style="vertical-align: bottom; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom;" valign="bottom"> </td> <td colspan="2" style="vertical-align: top;" valign="bottom"> <div style="text-align: center; font-weight: bold;">2020</div> </td> <td colspan="1" style="vertical-align: bottom; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom;" valign="bottom"> </td> <td colspan="2" style="vertical-align: top;" valign="bottom"> <div style="text-align: center;"><span style="font-weight: bold;">2019</span><br/> </div> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="2" rowspan="1" style="vertical-align: bottom; width: 10.13%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="text-align: center; font-weight: bold;">$’000</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="2" rowspan="1" style="vertical-align: bottom; width: 10.13%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="text-align: center; font-weight: bold;">$’000</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="2" rowspan="1" style="vertical-align: bottom; width: 10.13%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="text-align: center; font-weight: bold;">$’000</div> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>Salary and related expenses</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>687</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>5</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>—</div> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%; padding-bottom: 2px;" valign="bottom"> <div>Shared based compensation expense</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div>163</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div>—</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div>—</div> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%; background-color: rgb(204, 238, 255); padding-bottom: 4px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); padding-bottom: 4px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255); border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold;">850</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); font-weight: bold; border-bottom: 4px double rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); font-weight: bold; border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); font-weight: bold; border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255); border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold;">5</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); font-weight: bold; border-bottom: 4px double rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); font-weight: bold; border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); font-weight: bold; border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255); border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold;">—</div> </td> </tr> </table>

5270400

2108159 126218 50487 25000 1.00 25000 1.00

625000

<span style="font-family: 'Times New Roman'; font-size: 10pt; color: #000000;">Key management is comprised of executive officers and the board of directors who served during the reporting period.</span> <div style="font-family: 'Times New Roman'; font-size: 10pt;"><br/> </div> <table cellpadding="0" cellspacing="0" class="cfttable" style="font-family: 'Times New Roman'; font-size: 10pt; text-align: left; color: #000000; width: 100%;"> <tr> <td style="vertical-align: top; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="10" style="vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="text-align: center; font-weight: bold;">Year ended</div> <div style="text-align: center; font-weight: bold;">December 31,</div> </td> </tr> <tr> <td style="vertical-align: top;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom;" valign="bottom"> </td> <td colspan="2" style="vertical-align: top;" valign="bottom"> <div style="text-align: center;"> <span style="font-weight: bold;">2021</span><br/> </div> </td> <td colspan="1" style="vertical-align: bottom; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom;" valign="bottom"> </td> <td colspan="2" style="vertical-align: top;" valign="bottom"> <div style="text-align: center; font-weight: bold;">2020</div> </td> <td colspan="1" style="vertical-align: bottom; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom;" valign="bottom"> </td> <td colspan="2" style="vertical-align: top;" valign="bottom"> <div style="text-align: center;"><span style="font-weight: bold;">2019</span><br/> </div> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="2" rowspan="1" style="vertical-align: bottom; width: 10.13%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="text-align: center; font-weight: bold;">$’000</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="2" rowspan="1" style="vertical-align: bottom; width: 10.13%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="text-align: center; font-weight: bold;">$’000</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="2" rowspan="1" style="vertical-align: bottom; width: 10.13%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="text-align: center; font-weight: bold;">$’000</div> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>Salary and related expenses</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>687</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>5</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255);" valign="bottom"> <div>—</div> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%; padding-bottom: 2px;" valign="bottom"> <div>Shared based compensation expense</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div>163</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div>—</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div>—</div> </td> </tr> <tr> <td style="vertical-align: top; width: 64.65%; background-color: rgb(204, 238, 255); padding-bottom: 4px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); padding-bottom: 4px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255); border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold;">850</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); font-weight: bold; border-bottom: 4px double rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); font-weight: bold; border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); font-weight: bold; border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255); border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold;">5</div> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); font-weight: bold; border-bottom: 4px double rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); font-weight: bold; border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; width: 0.99%; background-color: rgb(204, 238, 255); font-weight: bold; border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9.14%; background-color: rgb(204, 238, 255); border-bottom: 4px double rgb(0, 0, 0);" valign="bottom"> <div style="font-weight: bold;">—</div> </td> </tr> </table>

687000 5000 0

163000

850000

5000

<div style="font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">17. Loss per share</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The basic loss per share is calculated by dividing the net loss attributable to shareholders by the weighted average number of shares in issue during the financial year as follows:</div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;"> <br/> </div> <table cellpadding="0" cellspacing="0" class="cfttable" style="font-family: 'Times New Roman'; font-size: 10pt; text-align: left; color: #000000; width: 100%;"> <tr> <td style="vertical-align: top; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="10" style="vertical-align: top; border-bottom: #000000 solid 2px;" valign="bottom"> <div style="text-align: center; font-weight: bold;">Year ended</div> <div style="text-align: center; font-weight: bold;">December 31,</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; padding-bottom: 2px; white-space: nowrap;" valign="bottom"> </td> </tr> <tr> <td style="vertical-align: top; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="2" style="vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="text-align: center; font-weight: bold;">2021</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="2" style="vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="text-align: center; font-weight: bold;">2020</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="2" style="vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="text-align: center; font-weight: bold;">2019</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; padding-bottom: 2px; white-space: nowrap;" valign="bottom"> </td> </tr> <tr> <td style="vertical-align: top; width: 64%; background-color: #CCEEFF;" valign="bottom"> <div>Loss attributable to shareholders (in $’000)</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" valign="bottom"> <div>(9,202</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF; white-space: nowrap;" valign="bottom"> <div>)</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" valign="bottom"> <div>(446</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF; white-space: nowrap;" valign="bottom"> <div>)</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" valign="bottom"> <div>(310</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF; white-space: nowrap;" valign="bottom"> <div>)</div> </td> </tr> <tr> <td style="vertical-align: top; width: 64%;" valign="bottom"> <div>Weighted average number of shares in issue<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1) (2)</sup></div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%;" valign="bottom"> <div>43,683,296</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%;" valign="bottom"> <div>28,359,368</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%;" valign="bottom"> <div>28,000,000</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; white-space: nowrap;" valign="bottom"> </td> </tr> <tr> <td style="vertical-align: top; width: 64%; background-color: #CCEEFF;" valign="bottom"> <div>Basic and diluted loss per share (in USD)</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" valign="bottom"> <div>(0.211</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF; white-space: nowrap;" valign="bottom"> <div>)</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" valign="bottom"> <div>(0.016</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF; white-space: nowrap;" valign="bottom"> <div>)</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" valign="bottom"> <div>(0.011</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF; white-space: nowrap;" valign="bottom"> <div>)</div> </td> </tr> </table> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> <br/> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;"><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)</sup> Share data for the years ended December 31, 2020 and 2019, has been revised to give effect to the share consolidation as explained in note 13, “Share capital and reserves”.</div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;"><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(2)</sup> Ordinary and preferred shares as of December 31, 2020 have been treated as a single class for the purpose of calculating loss per share as they contractually shared equally in the profits and losses of the entity.</div> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">For the years ended December 31, 2021, 2020 and 2019, basic and diluted loss per share are calculated on the weighted average number of shares issued and outstanding and exclude shares to be issued under the Share Option Plan, as the effect of including those shares would be anti-dilutive.</div>

<div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The basic loss per share is calculated by dividing the net loss attributable to shareholders by the weighted average number of shares in issue during the financial year as follows:</div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;"> <br/> </div> <table cellpadding="0" cellspacing="0" class="cfttable" style="font-family: 'Times New Roman'; font-size: 10pt; text-align: left; color: #000000; width: 100%;"> <tr> <td style="vertical-align: top; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="10" style="vertical-align: top; border-bottom: #000000 solid 2px;" valign="bottom"> <div style="text-align: center; font-weight: bold;">Year ended</div> <div style="text-align: center; font-weight: bold;">December 31,</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; padding-bottom: 2px; white-space: nowrap;" valign="bottom"> </td> </tr> <tr> <td style="vertical-align: top; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; padding-bottom: 2px;" valign="bottom"> </td> <td colspan="2" style="vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="text-align: center; font-weight: bold;">2021</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="2" style="vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="text-align: center; font-weight: bold;">2020</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> </td> <td colspan="2" style="vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"> <div style="text-align: center; font-weight: bold;">2019</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; padding-bottom: 2px; white-space: nowrap;" valign="bottom"> </td> </tr> <tr> <td style="vertical-align: top; width: 64%; background-color: #CCEEFF;" valign="bottom"> <div>Loss attributable to shareholders (in $’000)</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" valign="bottom"> <div>(9,202</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF; white-space: nowrap;" valign="bottom"> <div>)</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" valign="bottom"> <div>(446</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF; white-space: nowrap;" valign="bottom"> <div>)</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" valign="bottom"> <div>(310</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF; white-space: nowrap;" valign="bottom"> <div>)</div> </td> </tr> <tr> <td style="vertical-align: top; width: 64%;" valign="bottom"> <div>Weighted average number of shares in issue<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1) (2)</sup></div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%;" valign="bottom"> <div>43,683,296</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%;" valign="bottom"> <div>28,359,368</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; white-space: nowrap;" valign="bottom"> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%;" valign="bottom"> <div>28,000,000</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; white-space: nowrap;" valign="bottom"> </td> </tr> <tr> <td style="vertical-align: top; width: 64%; background-color: #CCEEFF;" valign="bottom"> <div>Basic and diluted loss per share (in USD)</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" valign="bottom"> <div>(0.211</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF; white-space: nowrap;" valign="bottom"> <div>)</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" valign="bottom"> <div>(0.016</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF; white-space: nowrap;" valign="bottom"> <div>)</div> </td> <td colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" valign="bottom"> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" valign="bottom"> </td> <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" valign="bottom"> <div>(0.011</div> </td> <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF; white-space: nowrap;" valign="bottom"> <div>)</div> </td> </tr> </table> <div style="font-family: 'Times New Roman'; font-size: 10pt;"> <br/> </div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;"><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)</sup> Share data for the years ended December 31, 2020 and 2019, has been revised to give effect to the share consolidation as explained in note 13, “Share capital and reserves”.</div> <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;"><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(2)</sup> Ordinary and preferred shares as of December 31, 2020 have been treated as a single class for the purpose of calculating loss per share as they contractually shared equally in the profits and losses of the entity.</div>

-9202000

-446000

-310000

43683296

28359368

28000000

-0.211

-0.016

-0.011

<div style="font-weight: bold; font-family: 'Times New Roman'; font-size: 10pt;">18. Events after the reporting date</div> <div> </div> <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt;">There are no events after the reporting date requiring disclosure in these consolidated financial statements.</div>

In 2018, the GH Research Ireland Limited issued 70,000,000 ordinary shares with a nominal value of €0.01 for which a receivable was recognized and the related cash flow occurred in 2019. Share information presented as of December 31, 2019 and 2020, and for the financial year then ended, is prior to the incorporation of GH Research PLC and relates solely to GH Ireland Research Limited and does not give effect to the 2.50-for-one share consolidation described below. Ordinary and preferred shares as of December 31, 2020 have been treated as a single class for the purpose of calculating loss per share as they contractually shared equally in the profits and losses of the entity. Share data for the years ended December 31, 2020 and 2019, has been revised to give effect to the share consolidation as explained in note 13, “Share capital and reserves”. Includes share-based compensation expense (see note 15, “Share-based compensation”). Includes depreciation expense (see note 10, “Property, plant and equipment”).